Hamel E - Search Results

1

Interaction of diazonamide A with tubulin.

Bai R, Cruz-Monserrate Z, Fenical W, Pettit GR, Hamel E. Bai R, et al. Among authors: hamel e. Arch Biochem Biophys. 2020 Feb 15;680:108217. doi: 10.1016/j.abb.2019.108217. Epub 2019 Dec 9. Arch Biochem Biophys. 2020. PMID: 31830440 Free PMC article.

2

Modulation of tubulin-nucleotide interactions by metal ions: comparison of beryllium with magnesium and initial studies with other cations.

Hamel E, Lin CM, Kenney S, Skehan P, Vaughns J. Hamel E, et al. Arch Biochem Biophys. 1992 Jun;295(2):327-39. doi: 10.1016/0003-9861(92)90525-2. Arch Biochem Biophys. 1992. PMID: 1586162

With microtubule-associated proteins (MAPs) BeSO4 and MgSO4 stimulated tubulin polymerization as compared to a reaction mixture without exogenously added metal ion, while beryllium fluoride had no effect (E. Hamel et al., 1991, Arch. Biochem. Biophys. 286, 57-69). E …

With microtubule-associated proteins (MAPs) BeSO4 and MgSO4 stimulated tubulin polymerization as compared to a reaction mixture without exog …

3

Dolastatin 15, a potent antimitotic depsipeptide derived from Dolabella auricularia. Interaction with tubulin and effects of cellular microtubules.

Bai R, Friedman SJ, Pettit GR, Hamel E. Bai R, et al. Among authors: hamel e. Biochem Pharmacol. 1992 Jun 23;43(12):2637-45. doi: 10.1016/0006-2952(92)90153-a. Biochem Pharmacol. 1992. PMID: 1632820

4

Highly variable effects of beryllium and beryllium fluoride on tubulin polymerization under different reaction conditions: comparison of assembly reactions dependent on microtubule-associated proteins, glycerol, dimethyl sulfoxide, and glutamate.

Hamel E, Lin CM, Kenney S, Skehan P. Hamel E, et al. Arch Biochem Biophys. 1991 Apr;286(1):57-69. doi: 10.1016/0003-9861(91)90008-7. Arch Biochem Biophys. 1991. PMID: 1680309

5

Halichondrin B and homohalichondrin B, marine natural products binding in the vinca domain of tubulin. Discovery of tubulin-based mechanism of action by analysis of differential cytotoxicity data.

Bai RL, Paull KD, Herald CL, Malspeis L, Pettit GR, Hamel E. Bai RL, et al. Among authors: hamel e. J Biol Chem. 1991 Aug 25;266(24):15882-9. J Biol Chem. 1991. PMID: 1874739 Free article.

6

Binding of dolastatin 10 to tubulin at a distinct site for peptide antimitotic agents near the exchangeable nucleotide and vinca alkaloid sites.

Bai RL, Pettit GR, Hamel E. Bai RL, et al. Among authors: hamel e. J Biol Chem. 1990 Oct 5;265(28):17141-9. J Biol Chem. 1990. PMID: 2211617 Free article.

7

Structure-activity studies with chiral isomers and with segments of the antimitotic marine peptide dolastatin 10.

Bai RL, Pettit GR, Hamel E. Bai RL, et al. Among authors: hamel e. Biochem Pharmacol. 1990 Oct 15;40(8):1859-64. doi: 10.1016/0006-2952(90)90367-t. Biochem Pharmacol. 1990. PMID: 2242019

8

Reexamination of the role of nonhydrolyzable guanosine 5'-triphosphate analogues in tubulin polymerization: reaction conditions are a critical factor for effective interactions at the exchangeable nucleotide site.

Hamel E, Lin CM. Hamel E, et al. Biochemistry. 1990 Mar 20;29(11):2720-9. doi: 10.1021/bi00463a015. Biochemistry. 1990. PMID: 2346744

9

Dolastatin 10, a powerful cytostatic peptide derived from a marine animal. Inhibition of tubulin polymerization mediated through the vinca alkaloid binding domain.

Bai R, Pettit GR, Hamel E. Bai R, et al. Among authors: hamel e. Biochem Pharmacol. 1990 Jun 15;39(12):1941-9. doi: 10.1016/0006-2952(90)90613-p. Biochem Pharmacol. 1990. PMID: 2353935

10

Identification of the cysteine residue of beta-tubulin alkylated by the antimitotic agent 2,4-dichlorobenzyl thiocyanate, facilitated by separation of the protein subunits of tubulin by hydrophobic column chromatography.

Bai RL, Lin CM, Nguyen NY, Liu TY, Hamel E. Bai RL, et al. Among authors: hamel e. Biochemistry. 1989 Jun 27;28(13):5606-12. doi: 10.1021/bi00439a040. Biochemistry. 1989. PMID: 2775724

Shown in previous studies to inhibit tubulin polymerization [Abraham, I., Dion, R. L., Duanmu, C., Gottesman, M. M., & Hamel, E. (1986) Proc. Natl. Acad. Sci. U.S.A. 83, 6839-6843] and to form a covalent bond preferentially with beta-tubulin [Bai, R., Duanmu, C. …

Shown in previous studies to inhibit tubulin polymerization [Abraham, I., Dion, R. L., Duanmu, C., Gottesman, M. M., & Hamel, …

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