HIF1A up-regulates the ADORA2B receptor on alternatively activated macrophages and contributes to pulmonary fibrosis.
Philip K, Mills TW, Davies J, Chen NY, Karmouty-Quintana H, Luo F, Molina JG, Amione-Guerra J, Sinha N, Guha A, Eltzschig HK, Blackburn MR.
Philip K, et al. Among authors: guha a.
FASEB J. 2017 Nov;31(11):4745-4758. doi: 10.1096/fj.201700219R. Epub 2017 Jul 12.
FASEB J. 2017.
PMID: 28701304
Free PMC article.
Although hypoxic conditions are present in IPF, hypoxia's role as a direct modulator of macrophage phenotype and identification of factors that regulate ADORA2B expression on AAMs in IPF is not well understood. ...-Y., Karmouty-Quintana, H., Luo, F., Molina, J. G., Amione- …
Although hypoxic conditions are present in IPF, hypoxia's role as a direct modulator of macrophage phenotype and identification of fa …