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ActRIIB:ALK4-Fc alleviates muscle dysfunction and comorbidities in murine models of neuromuscular disorders.
Li J, Fredericks M, Cannell M, Wang K, Sako D, Maguire MC, Grenha R, Liharska K, Krishnan L, Bloom T, Belcheva EP, Martinez PA, Castonguay R, Keates S, Alexander MJ, Choi H, Grinberg AV, Pearsall RS, Oh P, Kumar R, Suragani RN. Li J, et al. Among authors: grenha r. J Clin Invest. 2021 Feb 15;131(4):e138634. doi: 10.1172/JCI138634. J Clin Invest. 2021. PMID: 33586684 Free PMC article.
Sotatercept analog suppresses inflammation to reverse experimental pulmonary arterial hypertension.
Joshi SR, Liu J, Bloom T, Karaca Atabay E, Kuo TH, Lee M, Belcheva E, Spaits M, Grenha R, Maguire MC, Frost JL, Wang K, Briscoe SD, Alexander MJ, Herrin BR, Castonguay R, Pearsall RS, Andre P, Yu PB, Kumar R, Li G. Joshi SR, et al. Among authors: grenha r. Sci Rep. 2022 May 12;12(1):7803. doi: 10.1038/s41598-022-11435-x. Sci Rep. 2022. PMID: 35551212 Free PMC article.
Structures of activin ligand traps using natural sets of type I and type II TGFβ receptors.
Goebel EJ, Kattamuri C, Gipson GR, Krishnan L, Chavez M, Czepnik M, Maguire MC, Grenha R, Håkansson M, Logan DT, Grinberg AV, Sako D, Castonguay R, Kumar R, Thompson TB. Goebel EJ, et al. Among authors: grenha r. iScience. 2021 Dec 9;25(1):103590. doi: 10.1016/j.isci.2021.103590. eCollection 2022 Jan 21. iScience. 2021. PMID: 35005539 Free PMC article.
Structural characterization of an activin class ternary receptor complex reveals a third paradigm for receptor specificity.
Goebel EJ, Corpina RA, Hinck CS, Czepnik M, Castonguay R, Grenha R, Boisvert A, Miklossy G, Fullerton PT, Matzuk MM, Idone VJ, Economides AN, Kumar R, Hinck AP, Thompson TB. Goebel EJ, et al. Among authors: grenha r. Proc Natl Acad Sci U S A. 2019 Jul 30;116(31):15505-15513. doi: 10.1073/pnas.1906253116. Epub 2019 Jul 17. Proc Natl Acad Sci U S A. 2019. PMID: 31315975 Free PMC article.
Saposins utilize two strategies for lipid transfer and CD1 antigen presentation.
León L, Tatituri RV, Grenha R, Sun Y, Barral DC, Minnaard AJ, Bhowruth V, Veerapen N, Besra GS, Kasmar A, Peng W, Moody DB, Grabowski GA, Brenner MB. León L, et al. Among authors: grenha r. Proc Natl Acad Sci U S A. 2012 Mar 20;109(12):4357-64. doi: 10.1073/pnas.1200764109. Epub 2012 Feb 13. Proc Natl Acad Sci U S A. 2012. PMID: 22331868 Free PMC article.
Cadherin-11 regulates fibroblast inflammation.
Chang SK, Noss EH, Chen M, Gu Z, Townsend K, Grenha R, Leon L, Lee SY, Lee DM, Brenner MB. Chang SK, et al. Among authors: grenha r. Proc Natl Acad Sci U S A. 2011 May 17;108(20):8402-7. doi: 10.1073/pnas.1019437108. Epub 2011 May 2. Proc Natl Acad Sci U S A. 2011. PMID: 21536877 Free PMC article.
Hepatic FcRn regulates albumin homeostasis and susceptibility to liver injury.
Pyzik M, Rath T, Kuo TT, Win S, Baker K, Hubbard JJ, Grenha R, Gandhi A, Krämer TD, Mezo AR, Taylor ZS, McDonnell K, Nienaber V, Andersen JT, Mizoguchi A, Blumberg L, Purohit S, Jones SD, Christianson G, Lencer WI, Sandlie I, Kaplowitz N, Roopenian DC, Blumberg RS. Pyzik M, et al. Among authors: grenha r. Proc Natl Acad Sci U S A. 2017 Apr 4;114(14):E2862-E2871. doi: 10.1073/pnas.1618291114. Epub 2017 Mar 22. Proc Natl Acad Sci U S A. 2017. PMID: 28330995 Free PMC article.
16 results