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Selective vulnerability of Rich Club brain regions is an organizational principle of structural connectivity loss in Huntington's disease.
McColgan P, Seunarine KK, Razi A, Cole JH, Gregory S, Durr A, Roos RA, Stout JC, Landwehrmeyer B, Scahill RI, Clark CA, Rees G, Tabrizi SJ; Track-HD Investigators. McColgan P, et al. Among authors: gregory s. Brain. 2015 Nov;138(Pt 11):3327-44. doi: 10.1093/brain/awv259. Epub 2015 Sep 17. Brain. 2015. PMID: 26384928 Free PMC article.
Neuropsychiatry and White Matter Microstructure in Huntington's Disease.
Gregory S, Scahill RI, Seunarine KK, Stopford C, Zhang H, Zhang J, Orth M, Durr A, Roos RA, Langbehn DR, Long JD, Johnson H, Rees G, Tabrizi SJ, Craufurd D; Track-HD Investigators. Gregory S, et al. J Huntingtons Dis. 2015;4(3):239-49. doi: 10.3233/JHD-150160. J Huntingtons Dis. 2015. PMID: 26443926 Free PMC article.
Compensation in Preclinical Huntington's Disease: Evidence From the Track-On HD Study.
Klöppel S, Gregory S, Scheller E, Minkova L, Razi A, Durr A, Roos RA, Leavitt BR, Papoutsi M, Landwehrmeyer GB, Reilmann R, Borowsky B, Johnson H, Mills JA, Owen G, Stout J, Scahill RI, Long JD, Rees G, Tabrizi SJ; Track-On investigators. Klöppel S, et al. Among authors: gregory s. EBioMedicine. 2015 Aug 4;2(10):1420-9. doi: 10.1016/j.ebiom.2015.08.002. eCollection 2015 Oct. EBioMedicine. 2015. PMID: 26629536 Free PMC article.
Natural variation in sensory-motor white matter organization influences manifestations of Huntington's disease.
Orth M, Gregory S, Scahill RI, Mayer IS, Minkova L, Klöppel S, Seunarine KK, Boyd L, Borowsky B, Reilmann R, Bernhard Landwehrmeyer G, Leavitt BR, Roos RA, Durr A, Rees G, Rothwell JC, Langbehn D, Tabrizi SJ; TRACK-On Investigators. Orth M, et al. Among authors: gregory s. Hum Brain Mapp. 2016 Dec;37(12):4615-4628. doi: 10.1002/hbm.23332. Epub 2016 Aug 1. Hum Brain Mapp. 2016. PMID: 27477323 Free PMC article.
White matter predicts functional connectivity in premanifest Huntington's disease.
McColgan P, Gregory S, Razi A, Seunarine KK, Gargouri F, Durr A, Roos RA, Leavitt BR, Scahill RI, Clark CA, Tabrizi SJ, Rees G; Track On‐HD Investigators; Coleman A, Decolongon J, Fan M, Petkau T, Jauffret C, Justo D, Lehericy S, Nigaud K, Valabrègue R, Choonderbeek A, Hart EP, Hensman Moss DJ, Crawford H, Johnson E, Papoutsi M, Berna C, Reilmann R, Weber N, Stout J, Labuschagne I, Landwehrmeyer B, Orth M, Johnson H. McColgan P, et al. Among authors: gregory s. Ann Clin Transl Neurol. 2017 Jan 16;4(2):106-118. doi: 10.1002/acn3.384. eCollection 2017 Feb. Ann Clin Transl Neurol. 2017. PMID: 28168210 Free PMC article.
Operationalizing compensation over time in neurodegenerative disease.
Gregory S, Long JD, Klöppel S, Razi A, Scheller E, Minkova L, Papoutsi M, Mills JA, Durr A, Leavitt BR, Roos RAC, Stout JC, Scahill RI, Langbehn DR, Tabrizi SJ, Rees G. Gregory S, et al. Brain. 2017 Apr 1;140(4):1158-1165. doi: 10.1093/brain/awx022. Brain. 2017. PMID: 28334888 Free PMC article.
In pre-clinical Huntington's disease, normal behaviour is maintained despite neurodegeneration, suggesting a mechanism of compensation. Gregory, Long et al. present two mathematical models of compensation over time and their operationalisation for neuroimaging....
In pre-clinical Huntington's disease, normal behaviour is maintained despite neurodegeneration, suggesting a mechanism of compensatio …
Topological length of white matter connections predicts their rate of atrophy in premanifest Huntington's disease.
McColgan P, Seunarine KK, Gregory S, Razi A, Papoutsi M, Long JD, Mills JA, Johnson E, Durr A, Roos RA, Leavitt BR, Stout JC, Scahill RI, Clark CA, Rees G, Tabrizi SJ; Track-On HD Investigators. McColgan P, et al. Among authors: gregory s. JCI Insight. 2017 Apr 20;2(8):e92641. doi: 10.1172/jci.insight.92641. eCollection 2017 Apr 20. JCI Insight. 2017. PMID: 28422761 Free PMC article.
1,301 results