Operationalizing compensation over time in neurodegenerative disease

Sarah Gregory; Jeffrey D Long; Stefan Klöppel; Adeel Razi; Elisa Scheller; Lora Minkova; Marina Papoutsi; James A Mills; Alexandra Durr; Blair R Leavitt; Raymund A C Roos; Julie C Stout; Rachael I Scahill; Douglas R Langbehn; Sarah J Tabrizi; Geraint Rees

doi:10.1093/brain/awx022

Operationalizing compensation over time in neurodegenerative disease

Brain. 2017 Apr 1;140(4):1158-1165. doi: 10.1093/brain/awx022.

Authors

Sarah Gregory¹, Jeffrey D Long^{2

3}, Stefan Klöppel^{4

5

6}, Adeel Razi^{1

7}, Elisa Scheller^{4

5

8}, Lora Minkova^{4

5

8}, Marina Papoutsi⁹, James A Mills², Alexandra Durr¹⁰, Blair R Leavitt¹¹, Raymund A C Roos¹², Julie C Stout¹³, Rachael I Scahill⁹, Douglas R Langbehn^{2

3}, Sarah J Tabrizi⁹, Geraint Rees^{1

14}

Affiliations

¹ Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, London, UK.
² Department of Psychiatry, Carver College of Medicine, University of Iowa, Iowa, City, IA, USA.
³ Department of Biostatistics, College of Public Health, University of Iowa, Iowa City, IA, USA.
⁴ Albert-Ludwigs-University Freiburg, University Medical Center, Division Freiburg Brain Imaging, Freiburg, Germany.
⁵ Albert-Ludwigs-University Freiburg, University Medical Center, Department of Psychiatry and Psychotherapy, Freiburg, Germany.
⁶ University Hospital for Old Age Psychiatry, Murtenstrasse 21, 3010 Bern, Switzerland.
⁷ Department of Electronic Engineering, N.E.D University of Engineering and Technology, Karachi, Pakistan.
⁸ Albert-Ludwigs-University Freiburg, Department of Psychology, Laboratory for Biological and Personality Psychology, Freiburg, Germany.
⁹ Department of Neurodegenerative Disease, UCL Institute of Neurology, University College London, London, UK.
¹⁰ APHP Department of Genetics, Groupe Hospitalier Pitié-Salpêtrière, and Institut du Cerveau et de la Moelle, INSERM U1127, CNRS UMR7225, UPMC Université Paris VI UMR_S1127, Paris France.
¹¹ Centre for Molecular Medicine and Therapeutics, Department of Medical Genetics, University of British Columbia, Canada.
¹² Leiden University Medical Center, Department of Neurology, Leiden, The Netherlands.
¹³ School of Psychological Sciences and Institute of Clinical and Cognitive Neuroscience, Monash University, Melbourne, Australia.
¹⁴ Institute of Cognitive Neuroscience, University College London, London, UK.

Abstract

In pre-clinical Huntington's disease, normal behaviour is maintained despite neurodegeneration, suggesting a mechanism of compensation. Gregory, Long et al. present two mathematical models of compensation over time and their operationalisation for neuroimaging.

Keywords: Huntington’s disease; MRI; compensation; longitudinal analysis; neurodegeneration.

Operationalizing compensation over time in neurodegenerative disease

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