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CDK12 loss in cancer cells affects DNA damage response genes through premature cleavage and polyadenylation.
Krajewska M, Dries R, Grassetti AV, Dust S, Gao Y, Huang H, Sharma B, Day DS, Kwiatkowski N, Pomaville M, Dodd O, Chipumuro E, Zhang T, Greenleaf AL, Yuan GC, Gray NS, Young RA, Geyer M, Gerber SA, George RE. Krajewska M, et al. Among authors: greenleaf al. Nat Commun. 2019 Apr 15;10(1):1757. doi: 10.1038/s41467-019-09703-y. Nat Commun. 2019. PMID: 30988284 Free PMC article.
Covalent targeting of remote cysteine residues to develop CDK12 and CDK13 inhibitors.
Zhang T, Kwiatkowski N, Olson CM, Dixon-Clarke SE, Abraham BJ, Greifenberg AK, Ficarro SB, Elkins JM, Liang Y, Hannett NM, Manz T, Hao M, Bartkowiak B, Greenleaf AL, Marto JA, Geyer M, Bullock AN, Young RA, Gray NS. Zhang T, et al. Among authors: greenleaf al. Nat Chem Biol. 2016 Oct;12(10):876-84. doi: 10.1038/nchembio.2166. Epub 2016 Aug 29. Nat Chem Biol. 2016. PMID: 27571479 Free PMC article.
Engineering an analog-sensitive CDK12 cell line using CRISPR/Cas.
Bartkowiak B, Yan C, Greenleaf AL. Bartkowiak B, et al. Among authors: greenleaf al. Biochim Biophys Acta. 2015 Sep;1849(9):1179-87. doi: 10.1016/j.bbagrm.2015.07.010. Epub 2015 Jul 17. Biochim Biophys Acta. 2015. PMID: 26189575 Free PMC article.
The phosphoCTD-interacting domain of Topoisomerase I.
Wu J, Phatnani HP, Hsieh TS, Greenleaf AL. Wu J, et al. Among authors: greenleaf al. Biochem Biophys Res Commun. 2010 Jun 18;397(1):117-9. doi: 10.1016/j.bbrc.2010.05.081. Epub 2010 May 20. Biochem Biophys Res Commun. 2010. PMID: 20493173 Free PMC article.
94 results