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Variant-to-function analysis of the childhood obesity chr12q13 locus implicates rs7132908 as a causal variant within the 3' UTR of FAIM2.
Littleton SH, Trang KB, Volpe CM, Cook K, DeBruyne N, Maguire JA, Weidekamp MA, Hodge KM, Boehm K, Lu S, Chesi A, Bradfield JP, Pippin JA, Anderson SA, Wells AD, Pahl MC, Grant SFA. Littleton SH, et al. Among authors: grant sfa. Cell Genom. 2024 May 8;4(5):100556. doi: 10.1016/j.xgen.2024.100556. Epub 2024 May 1. Cell Genom. 2024. PMID: 38697123 Free article.
Osteoporosis GWAS-implicated DNM3 locus contextually regulates osteoblastic and chondrogenic fate of mesenchymal stem/progenitor cells through oscillating miR-199a-5p levels.
Kaur G, Pippin JA, Chang S, Redmond J, Chesi A, Wells AD, Maerz T, Grant SFA, Coleman RM, Hankenson KD, Wagley Y. Kaur G, et al. Among authors: grant sfa. JBMR Plus. 2024 Apr 10;8(5):ziae051. doi: 10.1093/jbmrpl/ziae051. eCollection 2024 May. JBMR Plus. 2024. PMID: 38686038 Free PMC article.
Perturbation of the insomnia WDR90 GWAS locus pinpoints rs3752495 as a causal variant influencing distal expression of neighboring gene, PIG-Q.
Sonti S, Littleton SH, Pahl MC, Zimmerman AJ, Chesi A, Palermo J, Lasconi C, Brown EB, Pippin JA, Wells AD, Doldur-Balli F, Pack AI, Gehrman PR, Keene AC, Grant SFA. Sonti S, et al. Among authors: grant sfa. Sleep. 2024 Apr 4:zsae085. doi: 10.1093/sleep/zsae085. Online ahead of print. Sleep. 2024. PMID: 38571402
GWAS-informed data integration and non-coding CRISPRi screen illuminate genetic etiology of bone mineral density.
Conery M, Pippin JA, Wagley Y, Trang K, Pahl MC, Villani DA, Favazzo LJ, Ackert-Bicknell CL, Zuscik MJ, Katsevich E, Wells AD, Zemel BS, Voight BF, Hankenson KD, Chesi A, Grant SFA. Conery M, et al. Among authors: grant sfa. bioRxiv [Preprint]. 2024 Mar 20:2024.03.19.585778. doi: 10.1101/2024.03.19.585778. bioRxiv. 2024. PMID: 38562830 Free PMC article. Preprint.
A framework for conducting time-varying genome-wide association studies: An application to body mass index across childhood in six multiethnic cohorts.
Burrows K, Heiskala A, Bradfield JP, Balkhiyarova Z, Ning L, Boissel M, Chan YM, Froguel P, Bonnefond A, Hakonarson H, Alves AC, Lawlor DA, Kaakinen M, Järvelin MR, Grant SFA, Tilling K, Prokopenko I, Sebert S, Canouil M, Warrington NM. Burrows K, et al. Among authors: grant sfa. medRxiv [Preprint]. 2024 Mar 16:2024.03.13.24304263. doi: 10.1101/2024.03.13.24304263. medRxiv. 2024. PMID: 38559031 Free PMC article. Preprint.
Metabolic links among milk, genes and gut.
Littleton SH, Grant SFA. Littleton SH, et al. Among authors: grant sfa. Nat Metab. 2024 Jan;6(1):12-13. doi: 10.1038/s42255-023-00958-w. Nat Metab. 2024. PMID: 38253930 No abstract available.
Trans-ancestral genome-wide association study of longitudinal pubertal height growth and shared heritability with adult health outcomes.
Bradfield JP, Kember RL, Ulrich A, Balkiyarova Z, Alyass A, Aris IM, Bell JA, Broadaway KA, Chen Z, Chai JF, Davies NM, Fernandez-Orth D, Bustamante M, Fore R, Ganguli A, Heiskala A, Hottenga JJ, Íñiguez C, Kobes S, Leinonen J, Lowry E, Lyytikainen LP, Mahajan A, Pitkänen N, Schnurr TM, Have CT, Strachan DP, Thiering E, Vogelezang S, Wade KH, Wang CA, Wong A, Holm LA, Chesi A, Choong C, Cruz M, Elliott P, Franks S, Frithioff-Bøjsøe C, Gauderman WJ, Glessner JT, Gilsanz V, Griesman K, Hanson RL, Kaakinen M, Kalkwarf H, Kelly A, Kindler J, Kähönen M, Lanca C, Lappe J, Lee NR, McCormack S, Mentch FD, Mitchell JA, Mononen N, Niinikoski H, Oken E, Pahkala K, Sim X, Teo YY, Baier LJ, van Beijsterveldt T, Adair LS, Boomsma DI, de Geus E, Guxens M, Eriksson JG, Felix JF, Gilliland FD, Biobank PM, Hansen T, Hardy R, Hivert MF, Holm JC, Jaddoe VWV, Järvelin MR, Lehtimäki T, Mackey DA, Meyre D, Mohlke KL, Mykkänen J, Oberfield S, Pennell CE, Perry JRB, Raitakari O, Rivadeneira F, Saw SM, Sebert S, Shepherd JA, Standl M, Sørensen TIA, Timpson NJ, Torrent M, Willemsen G, Hypponen E, Power C; Early Growth Genetics Consortium; McCarthy MI, Freathy RM, Widén E, Hakonarson H, Prokopenko I, Voight … See abstract for full author list ➔ Bradfield JP, et al. Among authors: grant sfa. Genome Biol. 2024 Jan 16;25(1):22. doi: 10.1186/s13059-023-03136-z. Genome Biol. 2024. PMID: 38229171 Free PMC article.
Patient-derived Colonoids From Disease-spared Tissue Retain Inflammatory Bowel Disease-specific Transcriptomic Signatures.
Karakasheva TA, Zhou Y, Xie HM, Soto GE, Johnson TD, Stoltz MA, Roach DM, Nema N, Umeweni CN, Naughton K, Dolinsky L, Pippin JA, Wells AD, Grant SFA, Ghanem L, Terry N, Muir AB, Hamilton KE. Karakasheva TA, et al. Among authors: grant sfa. Gastro Hep Adv. 2023;2(6):830-842. doi: 10.1016/j.gastha.2023.05.003. Epub 2023 May 25. Gastro Hep Adv. 2023. PMID: 37736163 Free PMC article.
330 results