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Discrimination of deletion to point cytokine mutants based on an array of cross-reactive receptors mimicking protein recognition by heparan sulfate.
Genua M, Garçon LA, Sergeeva YN, Saesen E, Musnier B, Buhot A, Billon M, Gout E, Sadir R, Lortat-Jacob H, Le Narvor C, Bonnaffé D, Livache T, Hou Y. Genua M, et al. Among authors: gout e. Anal Bioanal Chem. 2022 Jan;414(1):551-559. doi: 10.1007/s00216-021-03516-z. Epub 2021 Jul 13. Anal Bioanal Chem. 2022. PMID: 34258651
Expression and purification of recombinant extracellular sulfatase HSulf-2 allows deciphering of enzyme sub-domain coordinated role for the binding and 6-O-desulfation of heparan sulfate.
Seffouh A, El Masri R, Makshakova O, Gout E, Hassoun ZEO, Andrieu JP, Lortat-Jacob H, Vivès RR. Seffouh A, et al. Among authors: gout e. Cell Mol Life Sci. 2019 May;76(9):1807-1819. doi: 10.1007/s00018-019-03027-2. Epub 2019 Feb 20. Cell Mol Life Sci. 2019. PMID: 30788513
HS and Inflammation: A Potential Playground for the Sulfs?
El Masri R, Crétinon Y, Gout E, Vivès RR. El Masri R, et al. Among authors: gout e. Front Immunol. 2020 Apr 3;11:570. doi: 10.3389/fimmu.2020.00570. eCollection 2020. Front Immunol. 2020. PMID: 32318065 Free PMC article. Review.
Extracellular endosulfatase Sulf-2 harbors a chondroitin/dermatan sulfate chain that modulates its enzyme activity.
El Masri R, Seffouh A, Roelants C, Seffouh I, Gout E, Pérard J, Dalonneau F, Nishitsuji K, Noborn F, Nikpour M, Larson G, Crétinon Y, Friedel-Arboleas M, Uchimura K, Daniel R, Lortat-Jacob H, Filhol O, Vivès RR. El Masri R, et al. Among authors: gout e. Cell Rep. 2022 Mar 15;38(11):110516. doi: 10.1016/j.celrep.2022.110516. Cell Rep. 2022. PMID: 35294879 Free article.
IFNγ binding to extracellular matrix prevents fatal systemic toxicity.
Kemna J, Gout E, Daniau L, Lao J, Weißert K, Ammann S, Kühn R, Richter M, Molenda C, Sporbert A, Zocholl D, Klopfleisch R, Schütz A, Lortat-Jacob H, Aichele P, Kammertoens T, Blankenstein T. Kemna J, et al. Among authors: gout e. Nat Immunol. 2023 Mar;24(3):414-422. doi: 10.1038/s41590-023-01420-5. Epub 2023 Feb 2. Nat Immunol. 2023. PMID: 36732425 Free PMC article.
88 results