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The mitochondrial ATP synthase is a shared drug target for aging and dementia.
Goldberg J, Currais A, Prior M, Fischer W, Chiruta C, Ratliff E, Daugherty D, Dargusch R, Finley K, Esparza-Moltó PB, Cuezva JM, Maher P, Petrascheck M, Schubert D. Goldberg J, et al. Aging Cell. 2018 Apr;17(2):e12715. doi: 10.1111/acel.12715. Epub 2018 Jan 7. Aging Cell. 2018. PMID: 29316249 Free PMC article.
Geroneuroprotectors: Effective Geroprotectors for the Brain.
Schubert D, Currais A, Goldberg J, Finley K, Petrascheck M, Maher P. Schubert D, et al. Among authors: goldberg j. Trends Pharmacol Sci. 2018 Dec;39(12):1004-1007. doi: 10.1016/j.tips.2018.09.008. Epub 2018 Nov 13. Trends Pharmacol Sci. 2018. PMID: 30446211 Free PMC article. Review.
Elevating acetyl-CoA levels reduces aspects of brain aging.
Currais A, Huang L, Goldberg J, Petrascheck M, Ates G, Pinto-Duarte A, Shokhirev MN, Schubert D, Maher P. Currais A, et al. Among authors: goldberg j. Elife. 2019 Nov 19;8:e47866. doi: 10.7554/eLife.47866. Elife. 2019. PMID: 31742554 Free PMC article.
Intracellular amyloid toxicity induces oxytosis/ferroptosis regulated cell death.
Huang L, McClatchy DB, Maher P, Liang Z, Diedrich JK, Soriano-Castell D, Goldberg J, Shokhirev M, Yates JR 3rd, Schubert D, Currais A. Huang L, et al. Among authors: goldberg j. Cell Death Dis. 2020 Oct 6;11(10):828. doi: 10.1038/s41419-020-03020-9. Cell Death Dis. 2020. PMID: 33024077 Free PMC article.
3,267 results