Geroneuroprotectors: Effective Geroprotectors for the Brain

Trends Pharmacol Sci. 2018 Dec;39(12):1004-1007. doi: 10.1016/j.tips.2018.09.008. Epub 2018 Nov 13.

Abstract

Geroprotectors are compounds that slow the rate of biological aging and therefore may reduce the incidence of age-associated diseases such as Alzheimer's disease (AD). However, few have therapeutic efficacy in mammalian AD models. Here we describe the identification of geroneuroprotectors (GNPs), novel AD drug candidates that meet the criteria for geroprotectors.

Keywords: Alzheimer’s disease; aging; drug discovery; geroscience; multimorbidity; neuroprotection.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Aging / drug effects*
  • Aging / pathology
  • Alzheimer Disease / drug therapy*
  • Alzheimer Disease / prevention & control
  • Animals
  • Brain / drug effects*
  • Brain / growth & development
  • Drug Discovery / methods*
  • Humans
  • Neuroprotective Agents / pharmacology*
  • Neuroprotective Agents / therapeutic use

Substances

  • Neuroprotective Agents