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Page 1
Modulation of drug-linker design to enhance in vivo potency of homogeneous antibody-drug conjugates.
Pabst M, McDowell W, Manin A, Kyle A, Camper N, De Juan E, Parekh V, Rudge F, Makwana H, Kantner T, Parekh H, Michelet A, Sheng X, Popa G, Tucker C, Khayrzad F, Pollard D, Kozakowska K, Resende R, Jenkins A, Simoes F, Morris D, Williams P, Badescu G, Baker MP, Bird M, Frigerio M, Godwin A. Pabst M, et al. Among authors: godwin a. J Control Release. 2017 May 10;253:160-164. doi: 10.1016/j.jconrel.2017.02.027. Epub 2017 Mar 1. J Control Release. 2017. PMID: 28257988
In Vitro and In Vivo Evaluation of Cysteine Rebridged Trastuzumab-MMAE Antibody Drug Conjugates with Defined Drug-to-Antibody Ratios.
Bryant P, Pabst M, Badescu G, Bird M, McDowell W, Jamieson E, Swierkosz J, Jurlewicz K, Tommasi R, Henseleit K, Sheng X, Camper N, Manin A, Kozakowska K, Peciak K, Laurine E, Grygorash R, Kyle A, Morris D, Parekh V, Abhilash A, Choi JW, Edwards J, Frigerio M, Baker MP, Godwin A. Bryant P, et al. Among authors: godwin a. Mol Pharm. 2015 Jun 1;12(6):1872-9. doi: 10.1021/acs.molpharmaceut.5b00116. Epub 2015 May 5. Mol Pharm. 2015. PMID: 25894424
Incorporation of Hydrophilic Macrocycles Into Drug-Linker Reagents Produces Antibody-Drug Conjugates With Enhanced in vivo Performance.
Evans N, Grygorash R, Williams P, Kyle A, Kantner T, Pathak R, Sheng X, Simoes F, Makwana H, Resende R, de Juan E, Jenkins A, Morris D, Michelet A, Jewitt F, Rudge F, Camper N, Manin A, McDowell W, Pabst M, Godwin A, Frigerio M, Bird M. Evans N, et al. Among authors: godwin a. Front Pharmacol. 2022 Jun 17;13:764540. doi: 10.3389/fphar.2022.764540. eCollection 2022. Front Pharmacol. 2022. PMID: 35784686 Free PMC article.
Bridging disulfides for stable and defined antibody drug conjugates.
Badescu G, Bryant P, Bird M, Henseleit K, Swierkosz J, Parekh V, Tommasi R, Pawlisz E, Jurlewicz K, Farys M, Camper N, Sheng X, Fisher M, Grygorash R, Kyle A, Abhilash A, Frigerio M, Edwards J, Godwin A. Badescu G, et al. Among authors: godwin a. Bioconjug Chem. 2014 Jun 18;25(6):1124-36. doi: 10.1021/bc500148x. Epub 2014 May 23. Bioconjug Chem. 2014. PMID: 24791606
Site-specific PEGylation at histidine tags.
Cong Y, Pawlisz E, Bryant P, Balan S, Laurine E, Tommasi R, Singh R, Dubey S, Peciak K, Bird M, Sivasankar A, Swierkosz J, Muroni M, Heidelberger S, Farys M, Khayrzad F, Edwards J, Badescu G, Hodgson I, Heise C, Somavarapu S, Liddell J, Powell K, Zloh M, Choi JW, Godwin A, Brocchini S. Cong Y, et al. Among authors: godwin a. Bioconjug Chem. 2012 Feb 15;23(2):248-63. doi: 10.1021/bc200530x. Epub 2012 Feb 6. Bioconjug Chem. 2012. PMID: 22243664
A new reagent for stable thiol-specific conjugation.
Badescu G, Bryant P, Swierkosz J, Khayrzad F, Pawlisz E, Farys M, Cong Y, Muroni M, Rumpf N, Brocchini S, Godwin A. Badescu G, et al. Among authors: godwin a. Bioconjug Chem. 2014 Mar 19;25(3):460-9. doi: 10.1021/bc400245v. Epub 2014 Feb 11. Bioconjug Chem. 2014. PMID: 24512057
Fab-PEG-Fab as a potential antibody mimetic.
Khalili H, Godwin A, Choi JW, Lever R, Khaw PT, Brocchini S. Khalili H, et al. Among authors: godwin a. Bioconjug Chem. 2013 Nov 20;24(11):1870-82. doi: 10.1021/bc400246z. Epub 2013 Nov 4. Bioconjug Chem. 2013. PMID: 24073593
Comparative binding of disulfide-bridged PEG-Fabs.
Khalili H, Godwin A, Choi JW, Lever R, Brocchini S. Khalili H, et al. Among authors: godwin a. Bioconjug Chem. 2012 Nov 21;23(11):2262-77. doi: 10.1021/bc300372r. Epub 2012 Oct 18. Bioconjug Chem. 2012. PMID: 22994419
Site-specific PEGylation of native disulfide bonds in therapeutic proteins.
Shaunak S, Godwin A, Choi JW, Balan S, Pedone E, Vijayarangam D, Heidelberger S, Teo I, Zloh M, Brocchini S. Shaunak S, et al. Among authors: godwin a. Nat Chem Biol. 2006 Jun;2(6):312-3. doi: 10.1038/nchembio786. Epub 2006 Apr 23. Nat Chem Biol. 2006. PMID: 16633351
619 results