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Autistic-like behavior and cerebellar dysfunction in Bmal1 mutant mice ameliorated by mTORC1 inhibition.
Liu D, Nanclares C, Simbriger K, Fang K, Lorsung E, Le N, Amorim IS, Chalkiadaki K, Pathak SS, Li J, Gewirtz JC, Jin VX, Kofuji P, Araque A, Orr HT, Gkogkas CG, Cao R. Liu D, et al. Among authors: gkogkas cg. Mol Psychiatry. 2023 Sep;28(9):3727-3738. doi: 10.1038/s41380-022-01499-6. Epub 2022 Mar 17. Mol Psychiatry. 2023. PMID: 35301425 Free PMC article.
Metformin ameliorates core deficits in a mouse model of fragile X syndrome.
Gantois I, Khoutorsky A, Popic J, Aguilar-Valles A, Freemantle E, Cao R, Sharma V, Pooters T, Nagpal A, Skalecka A, Truong VT, Wiebe S, Groves IA, Jafarnejad SM, Chapat C, McCullagh EA, Gamache K, Nader K, Lacaille JC, Gkogkas CG, Sonenberg N. Gantois I, et al. Among authors: gkogkas cg. Nat Med. 2017 Jun;23(6):674-677. doi: 10.1038/nm.4335. Epub 2017 May 15. Nat Med. 2017. PMID: 28504725 Free article.
Monitoring translation in synaptic fractions using a ribosome profiling strategy.
Simbriger K, Amorim IS, Chalkiadaki K, Lach G, Jafarnejad SM, Khoutorsky A, Gkogkas CG. Simbriger K, et al. Among authors: gkogkas cg. J Neurosci Methods. 2020 Jan 1;329:108456. doi: 10.1016/j.jneumeth.2019.108456. Epub 2019 Oct 11. J Neurosci Methods. 2020. PMID: 31610213 Free PMC article.
Raptor-Mediated Proteasomal Degradation of Deamidated 4E-BP2 Regulates Postnatal Neuronal Translation and NF-κB Activity.
Kouloulia S, Hallin EI, Simbriger K, Amorim IS, Lach G, Amvrosiadis T, Chalkiadaki K, Kampaite A, Truong VT, Hooshmandi M, Jafarnejad SM, Skehel P, Kursula P, Khoutorsky A, Gkogkas CG. Kouloulia S, et al. Among authors: gkogkas cg. Cell Rep. 2019 Dec 10;29(11):3620-3635.e7. doi: 10.1016/j.celrep.2019.11.023. Cell Rep. 2019. PMID: 31825840 Free PMC article.
4E-BP2-dependent translation in cerebellar Purkinje cells controls spatial memory but not autism-like behaviors.
Hooshmandi M, Truong VT, Fields E, Thomas RE, Wong C, Sharma V, Gantois I, Soriano Roque P, Chalkiadaki K, Wu N, Chakraborty A, Tahmasebi S, Prager-Khoutorsky M, Sonenberg N, Suvrathan A, Watt AJ, Gkogkas CG, Khoutorsky A. Hooshmandi M, et al. Among authors: gkogkas cg. Cell Rep. 2021 Apr 27;35(4):109036. doi: 10.1016/j.celrep.2021.109036. Cell Rep. 2021. PMID: 33910008 Free article.
51 results