Regulation of mRNA translation in stem cells; links to brain disorders

Elpida Statoulla; Kleanthi Chalkiadaki; Dimitris Karozis; Christos G Gkogkas

doi:10.1016/j.cellsig.2021.110166

Regulation of mRNA translation in stem cells; links to brain disorders

Cell Signal. 2021 Dec:88:110166. doi: 10.1016/j.cellsig.2021.110166. Epub 2021 Oct 5.

Authors

Elpida Statoulla¹, Kleanthi Chalkiadaki¹, Dimitris Karozis¹, Christos G Gkogkas²

Affiliations

¹ Division of Biomedical Research, Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology-Hellas, University Campus, 45110 Ioannina, Greece.
² Division of Biomedical Research, Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology-Hellas, University Campus, 45110 Ioannina, Greece. Electronic address: cgkogkas@imbb.forth.gr.

PMID: 34624487
DOI: 10.1016/j.cellsig.2021.110166

Abstract

Translational control of gene expression is emerging as a cardinal step in the regulation of protein abundance. Especially for embryonic (ESC) and neuronal stem cells (NSC), regulation of mRNA translation is involved in the maintenance of pluripotency but also differentiation. For neuronal stem cells this regulation is linked to the various neuronal subtypes that arise in the developing brain and is linked to numerous brain disorders. Herein, we review translational control mechanisms in ESCs and NSCs during development and differentiation, and briefly discuss their link to brain disorders.

Keywords: Brain disorders; Neural stem cells; Stem cells; Translational control; mRNA translation.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Brain Diseases* / genetics
Brain Diseases* / metabolism
Cell Differentiation / genetics
Humans
Neurons / metabolism
Protein Biosynthesis*
Stem Cells