Gediya L - Search Results

1

First MNKs degrading agents block phosphorylation of eIF4E, induce apoptosis, inhibit cell growth, migration and invasion in triple negative and Her2-overexpressing breast cancer cell lines.

Ramalingam S, Gediya L, Kwegyir-Afful AK, Ramamurthy VP, Purushottamachar P, Mbatia H, Njar VC. Ramalingam S, et al. Among authors: gediya l. Oncotarget. 2014 Jan 30;5(2):530-43. doi: 10.18632/oncotarget.1528. Oncotarget. 2014. PMID: 24504069 Free PMC article.

2

Simultaneous targeting of androgen receptor (AR) and MAPK-interacting kinases (MNKs) by novel retinamides inhibits growth of human prostate cancer cell lines.

Ramamurthy VP, Ramalingam S, Gediya L, Kwegyir-Afful AK, Njar VC. Ramamurthy VP, et al. Among authors: gediya l. Oncotarget. 2015 Feb 20;6(5):3195-210. doi: 10.18632/oncotarget.3084. Oncotarget. 2015. PMID: 25605250 Free PMC article.

3

VN/14-1 induces ER stress and autophagy in HP-LTLC human breast cancer cells and has excellent oral pharmacokinetic profile in female Sprague Dawley rats.

Godbole AM, Ramalingam S, Ramamurthy VP, Khandelwal A, Bruno RD, Upreti VV, Gediya LK, Purushottamachar P, Mbatia HW, Addya S, Ambulos N, Njar VC. Godbole AM, et al. Among authors: gediya lk. Eur J Pharmacol. 2014 Jul 5;734:98-104. doi: 10.1016/j.ejphar.2014.04.004. Epub 2014 Apr 12. Eur J Pharmacol. 2014. PMID: 24726842 Free PMC article.

4

Novel galeterone analogs act independently of AR and AR-V7 for the activation of the unfolded protein response and induction of apoptosis in the CWR22Rv1 prostate cancer cell model.

McCarty DJ, Huang W, Kane MA, Purushottamachar P, Gediya LK, Njar VCO. McCarty DJ, et al. Among authors: gediya lk. Oncotarget. 2017 Aug 1;8(51):88501-88516. doi: 10.18632/oncotarget.19762. eCollection 2017 Oct 24. Oncotarget. 2017. PMID: 29179452 Free PMC article.

5

The retinamide VNLG-152 inhibits f-AR/AR-V7 and MNK-eIF4E signaling pathways to suppress EMT and castration-resistant prostate cancer xenograft growth.

Ramamurthy VP, Ramalingam S, Gediya LK, Njar VCO. Ramamurthy VP, et al. Among authors: gediya lk. FEBS J. 2018 Mar;285(6):1051-1063. doi: 10.1111/febs.14383. Epub 2018 Feb 3. FEBS J. 2018. PMID: 29323792 Free PMC article.

6

Retinoic acid metabolism blocking agents (RAMBAs) for treatment of cancer and dermatological diseases.

Njar VC, Gediya L, Purushottamachar P, Chopra P, Vasaitis TS, Khandelwal A, Mehta J, Huynh C, Belosay A, Patel J. Njar VC, et al. Among authors: gediya l. Bioorg Med Chem. 2006 Jul 1;14(13):4323-40. doi: 10.1016/j.bmc.2006.02.041. Epub 2006 Mar 10. Bioorg Med Chem. 2006. PMID: 16530416 Review.

7

Novel retinoic acid metabolism blocking agents endowed with multiple biological activities are efficient growth inhibitors of human breast and prostate cancer cells in vitro and a human breast tumor xenograft in nude mice.

Patel JB, Huynh CK, Handratta VD, Gediya LK, Brodie AM, Goloubeva OG, Clement OO, Nanne IP, Soprano DR, Njar VC. Patel JB, et al. J Med Chem. 2004 Dec 30;47(27):6716-29. doi: 10.1021/jm0401457. J Med Chem. 2004. PMID: 15615521

8

A new simple and high-yield synthesis of suberoylanilide hydroxamic acid and its inhibitory effect alone or in combination with retinoids on proliferation of human prostate cancer cells.

Gediya LK, Chopra P, Purushottamachar P, Maheshwari N, Njar VC. Gediya LK, et al. J Med Chem. 2005 Jul 28;48(15):5047-51. doi: 10.1021/jm058214k. J Med Chem. 2005. PMID: 16033284

9

First pharmacophore-based identification of androgen receptor down-regulating agents: discovery of potent anti-prostate cancer agents.

Purushottamachar P, Khandelwal A, Chopra P, Maheshwari N, Gediya LK, Vasaitis TS, Bruno RD, Clement OO, Njar VC. Purushottamachar P, et al. Bioorg Med Chem. 2007 May 15;15(10):3413-21. doi: 10.1016/j.bmc.2007.03.019. Epub 2007 Mar 13. Bioorg Med Chem. 2007. PMID: 17383188 Free PMC article.

10

Improved synthesis of histone deacetylase inhibitors (HDIs) (MS-275 and CI-994) and inhibitory effects of HDIs alone or in combination with RAMBAs or retinoids on growth of human LNCaP prostate cancer cells and tumor xenografts.

Gediya LK, Belosay A, Khandelwal A, Purushottamachar P, Njar VC. Gediya LK, et al. Bioorg Med Chem. 2008 Mar 15;16(6):3352-60. doi: 10.1016/j.bmc.2007.12.007. Epub 2007 Dec 8. Bioorg Med Chem. 2008. PMID: 18166465 Free PMC article.

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