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Discovery of a Candidate Containing an (S)-3,3-Difluoro-1-(4-methylpiperazin-1-yl)-2,3-dihydro-1H-inden Scaffold as a Highly Potent Pan-Inhibitor of the BCR-ABL Kinase Including the T315I-Resistant Mutant for the Treatment of Chronic Myeloid Leukemia.
Zhang D, Li P, Gao Y, Song Y, Zhu Y, Su H, Yang B, Li L, Li G, Gong N, Lu Y, Shao H, Yu C, Huang H. Zhang D, et al. Among authors: gao y. J Med Chem. 2021 Jun 10;64(11):7434-7452. doi: 10.1021/acs.jmedchem.1c00082. Epub 2021 May 19. J Med Chem. 2021. PMID: 34011155
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