Taking advantage of the aromatisation of 7-diethylamino-4-methyl-3,4-dihydrocoumarin in the fluorescence sensing of superoxide anion

Yuchen Wang; Jianyi Han; Yanzhao Xu; Yongxin Gao; Hui Wen; Huaqing Cui

doi:10.1039/d0cc02282a

Taking advantage of the aromatisation of 7-diethylamino-4-methyl-3,4-dihydrocoumarin in the fluorescence sensing of superoxide anion

Chem Commun (Camb). 2020 Sep 4;56(68):9827-9829. doi: 10.1039/d0cc02282a. Epub 2020 Jul 27.

Authors

Yuchen Wang¹, Jianyi Han, Yanzhao Xu, Yongxin Gao, Hui Wen, Huaqing Cui

Affiliation

¹ State Key Laboratory of Bioactive Substances and Function of Natural Medicine, Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences, 1 Xiannongtan Street, Beijing, 100050, China. hcui@imm.ac.cn wenhui@imm.ac.cn.

PMID: 32716414
DOI: 10.1039/d0cc02282a

Abstract

The aromatisation of 7-diethylamino-3,4-dihydrocoumarin provides an alternative fluorescent probing technique to selectively detect the concentration of superoxide anion in solution. In addition, we reported the advantage of evaluating O₂˙^- sensing probes in anhydrous DMSO instead of in aqueous buffers when using KO₂ as the surrogate of O₂˙^-.

MeSH terms

Anions / chemistry
Coumarins / chemistry*
Fluorescent Dyes / chemistry
Oxides / chemistry
Potassium Compounds / chemistry
Spectrometry, Fluorescence / methods*
Superoxides / analysis*
Superoxides / chemistry
Water / chemistry

Substances

Anions
Coumarins
Fluorescent Dyes
Oxides
Potassium Compounds
Water
Superoxides
potassium oxide
3,4-dihydrocoumarin