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The RNA-binding protein SRSF3 has an essential role in megakaryocyte maturation and platelet production.
Heazlewood SY, Ahmad T, Mohenska M, Guo BB, Gangatirkar P, Josefsson EC, Ellis SL, Ratnadiwakara M, Cao H, Cao B, Heazlewood CK, Williams B, Fulton M, White JF, Ramialison M, Nilsson SK, Änkö ML. Heazlewood SY, et al. Among authors: gangatirkar p. Blood. 2022 Mar 3;139(9):1359-1373. doi: 10.1182/blood.2021013826. Blood. 2022. PMID: 34852174 Free PMC article.
Altered B-lymphopoiesis in mice with deregulated thrombopoietin signaling.
Au AE, Lebois M, Sim SA, Cannon P, Corbin J, Gangatirkar P, Hyland CD, Moujalled D, Rutgersson A, Yassinson F, Kile BT, Mason KD, Ng AP, Alexander WS, Josefsson EC. Au AE, et al. Among authors: gangatirkar p. Sci Rep. 2017 Nov 2;7(1):14953. doi: 10.1038/s41598-017-15023-2. Sci Rep. 2017. PMID: 29097774 Free PMC article.
Intrinsic apoptosis circumvents the functional decline of circulating platelets but does not cause the storage lesion.
Pleines I, Lebois M, Gangatirkar P, Au AE, Lane RM, Henley KJ, Kauppi M, Corbin J, Cannon P, Bernardini J, Alwis I, Jarman KE, Ellis S, Metcalf D, Jackson SP, Schoenwaelder SM, Kile BT, Josefsson EC. Pleines I, et al. Among authors: gangatirkar p. Blood. 2018 Jul 12;132(2):197-209. doi: 10.1182/blood-2017-11-816355. Epub 2018 May 21. Blood. 2018. PMID: 29784641 Free article.
Targeting platelets for improved outcome in KRAS-driven lung adenocarcinoma.
Hyslop SR, Alexander M, Thai AA, Kersbergen A, Kueh AJ, Herold MJ, Corbin J, Gangatirkar P, Ng AP, Solomon BJ, Alexander WS, Sutherland KD, Josefsson EC. Hyslop SR, et al. Among authors: gangatirkar p. Oncogene. 2020 Jul;39(29):5177-5186. doi: 10.1038/s41388-020-1357-6. Epub 2020 Jun 13. Oncogene. 2020. PMID: 32535617
Membrane budding is a major mechanism of in vivo platelet biogenesis.
Potts KS, Farley A, Dawson CA, Rimes J, Biben C, de Graaf C, Potts MA, Stonehouse OJ, Carmagnac A, Gangatirkar P, Josefsson EC, Anttila C, Amann-Zalcenstein D, Naik S, Alexander WS, Hilton DJ, Hawkins ED, Taoudi S. Potts KS, et al. Among authors: gangatirkar p. J Exp Med. 2020 Sep 7;217(9):e20191206. doi: 10.1084/jem.20191206. J Exp Med. 2020. PMID: 32706855 Free PMC article.
A role for pericytes as microenvironmental regulators of human skin tissue regeneration.
Paquet-Fifield S, Schlüter H, Li A, Aitken T, Gangatirkar P, Blashki D, Koelmeyer R, Pouliot N, Palatsides M, Ellis S, Brouard N, Zannettino A, Saunders N, Thompson N, Li J, Kaur P. Paquet-Fifield S, et al. Among authors: gangatirkar p. J Clin Invest. 2009 Sep;119(9):2795-806. doi: 10.1172/JCI38535. Epub 2009 Aug 3. J Clin Invest. 2009. PMID: 19652362 Free PMC article.
A missense mutation in the MLKL brace region promotes lethal neonatal inflammation and hematopoietic dysfunction.
Hildebrand JM, Kauppi M, Majewski IJ, Liu Z, Cox AJ, Miyake S, Petrie EJ, Silk MA, Li Z, Tanzer MC, Brumatti G, Young SN, Hall C, Garnish SE, Corbin J, Stutz MD, Di Rago L, Gangatirkar P, Josefsson EC, Rigbye K, Anderton H, Rickard JA, Tripaydonis A, Sheridan J, Scerri TS, Jackson VE, Czabotar PE, Zhang JG, Varghese L, Allison CC, Pellegrini M, Tannahill GM, Hatchell EC, Willson TA, Stockwell D, de Graaf CA, Collinge J, Hilton A, Silke N, Spall SK, Chau D, Athanasopoulos V, Metcalf D, Laxer RM, Bassuk AG, Darbro BW, Fiatarone Singh MA, Vlahovich N, Hughes D, Kozlovskaia M, Ascher DB, Warnatz K, Venhoff N, Thiel J, Biben C, Blum S, Reveille J, Hildebrand MS, Vinuesa CG, McCombe P, Brown MA, Kile BT, McLean C, Bahlo M, Masters SL, Nakano H, Ferguson PJ, Murphy JM, Alexander WS, Silke J. Hildebrand JM, et al. Among authors: gangatirkar p. Nat Commun. 2020 Jun 19;11(1):3150. doi: 10.1038/s41467-020-16819-z. Nat Commun. 2020. PMID: 32561755 Free PMC article.
17 results