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Page 1
Design of Diverse Asymmetric Pockets in De Novo Homo-oligomeric Proteins.
Gerben SR, Borst AJ, Hicks DR, Moczygemba I, Feldman D, Coventry B, Yang W, Bera AK, Miranda M, Kang A, Nguyen H, Baker D. Gerben SR, et al. Biochemistry. 2023 Jan 17;62(2):358-368. doi: 10.1021/acs.biochem.2c00497. Epub 2023 Jan 10. Biochemistry. 2023. PMID: 36627259 Free PMC article.
De novo design of protein homodimers containing tunable symmetric protein pockets.
Hicks DR, Kennedy MA, Thompson KA, DeWitt M, Coventry B, Kang A, Bera AK, Brunette TJ, Sankaran B, Stoddard B, Baker D. Hicks DR, et al. Proc Natl Acad Sci U S A. 2022 Jul 26;119(30):e2113400119. doi: 10.1073/pnas.2113400119. Epub 2022 Jul 21. Proc Natl Acad Sci U S A. 2022. PMID: 35862457 Free PMC article.
De novo design of tyrosine and serine kinase-driven protein switches.
Woodall NB, Weinberg Z, Park J, Busch F, Johnson RS, Feldbauer MJ, Murphy M, Ahlrichs M, Yousif I, MacCoss MJ, Wysocki VH, El-Samad H, Baker D. Woodall NB, et al. Nat Struct Mol Biol. 2021 Sep;28(9):762-770. doi: 10.1038/s41594-021-00649-8. Epub 2021 Sep 13. Nat Struct Mol Biol. 2021. PMID: 34518698 Free PMC article.
Designed proteins assemble antibodies into modular nanocages.
Divine R, Dang HV, Ueda G, Fallas JA, Vulovic I, Sheffler W, Saini S, Zhao YT, Raj IX, Morawski PA, Jennewein MF, Homad LJ, Wan YH, Tooley MR, Seeger F, Etemadi A, Fahning ML, Lazarovits J, Roederer A, Walls AC, Stewart L, Mazloomi M, King NP, Campbell DJ, McGuire AT, Stamatatos L, Ruohola-Baker H, Mathieu J, Veesler D, Baker D. Divine R, et al. Science. 2021 Apr 2;372(6537):eabd9994. doi: 10.1126/science.abd9994. Science. 2021. PMID: 33795432 Free PMC article.
Designed proteins assemble antibodies into modular nanocages.
Divine R, Dang HV, Ueda G, Fallas JA, Vulovic I, Sheffler W, Saini S, Zhao YT, Raj IX, Morawski PA, Jennewein MF, Homad LJ, Wan YH, Tooley MR, Seeger F, Etemadi A, Fahning ML, Lazarovits J, Roederer A, Walls AC, Stewart L, Mazloomi M, King NP, Campbell DJ, McGuire AT, Stamatatos L, Ruohola-Baker H, Mathieu J, Veesler D, Baker D. Divine R, et al. bioRxiv [Preprint]. 2020 Dec 1:2020.12.01.406611. doi: 10.1101/2020.12.01.406611. bioRxiv. 2020. PMID: 33299994 Free PMC article. Updated. Preprint.
147 results