Funamoto S - Search Results

1

A tailored tetravalent peptide displays dual functions to inhibit amyloid β production and aggregation.

Sato W, Watanabe-Takahashi M, Murata T, Utsunomiya-Tate N, Motoyama J, Anzai M, Ishihara S, Nishioka N, Uchiyama H, Togashi J, Nishihara S, Kawasaki K, Saito T, Saido TC, Funamoto S, Nishikawa K. Sato W, et al. Among authors: funamoto s. Commun Biol. 2023 Apr 8;6(1):383. doi: 10.1038/s42003-023-04771-9. Commun Biol. 2023. PMID: 37031306 Free PMC article.

2

Substrate ectodomain is critical for substrate preference and inhibition of γ-secretase.

Funamoto S, Sasaki T, Ishihara S, Nobuhara M, Nakano M, Watanabe-Takahashi M, Saito T, Kakuda N, Miyasaka T, Nishikawa K, Saido TC, Ihara Y. Funamoto S, et al. Nat Commun. 2013;4:2529. doi: 10.1038/ncomms3529. Nat Commun. 2013. PMID: 24108142 Free PMC article.

3

A potential defense mechanism against amyloid deposition in cerebellum.

Shahnur A, Nakano M, Ishihara S, Kakuda N, Miyasaka T, Uchiyama H, Shirai Y, Moniruzzaman M, Saito T, Saido TC, Nishimura M, Funamoto S. Shahnur A, et al. Among authors: funamoto s. Biochem Biophys Res Commun. 2021 Jan 8;535:25-32. doi: 10.1016/j.bbrc.2020.12.036. Epub 2020 Dec 16. Biochem Biophys Res Commun. 2021. PMID: 33340762

4

A nontoxigenic form of Shiga toxin 2 suppresses the production of amyloid β by altering the intracellular transport of amyloid precursor protein through its receptor-binding B-subunit.

Sato W, Watanabe-Takahashi M, Hamabata T, Furukawa K, Funamoto S, Nishikawa K. Sato W, et al. Among authors: funamoto s. Biochem Biophys Res Commun. 2021 Jun 11;557:247-253. doi: 10.1016/j.bbrc.2021.04.015. Epub 2021 Apr 21. Biochem Biophys Res Commun. 2021. PMID: 33894410

5

Truncated carboxyl-terminal fragments of beta-amyloid precursor protein are processed to amyloid beta-proteins 40 and 42.

Funamoto S, Morishima-Kawashima M, Tanimura Y, Hirotani N, Saido TC, Ihara Y. Funamoto S, et al. Biochemistry. 2004 Oct 26;43(42):13532-40. doi: 10.1021/bi049399k. Biochemistry. 2004. PMID: 15491160

6

The A673T mutation in the amyloid precursor protein reduces the production of β-amyloid protein from its β-carboxyl terminal fragment in cells.

Kokawa A, Ishihara S, Fujiwara H, Nobuhara M, Iwata M, Ihara Y, Funamoto S. Kokawa A, et al. Among authors: funamoto s. Acta Neuropathol Commun. 2015 Nov 4;3:66. doi: 10.1186/s40478-015-0247-6. Acta Neuropathol Commun. 2015. PMID: 26531305 Free PMC article.

7

Alanine substitutions in the GXXXG motif alter C99 cleavage by γ-secretase but not its dimerization.

Higashide H, Ishihara S, Nobuhara M, Ihara Y, Funamoto S. Higashide H, et al. Among authors: funamoto s. J Neurochem. 2017 Mar;140(6):955-962. doi: 10.1111/jnc.13942. Epub 2017 Jan 30. J Neurochem. 2017. PMID: 28032911 Free article.

8

Glycosylation status of nicastrin influences catalytic activity and substrate preference of γ-secretase.

Moniruzzaman M, Ishihara S, Nobuhara M, Higashide H, Funamoto S. Moniruzzaman M, et al. Among authors: funamoto s. Biochem Biophys Res Commun. 2018 Jul 7;502(1):98-103. doi: 10.1016/j.bbrc.2018.05.126. Epub 2018 May 25. Biochem Biophys Res Commun. 2018. PMID: 29787759

9

gamma-Secretase: successive tripeptide and tetrapeptide release from the transmembrane domain of beta-carboxyl terminal fragment.

Takami M, Nagashima Y, Sano Y, Ishihara S, Morishima-Kawashima M, Funamoto S, Ihara Y. Takami M, et al. Among authors: funamoto s. J Neurosci. 2009 Oct 14;29(41):13042-52. doi: 10.1523/JNEUROSCI.2362-09.2009. J Neurosci. 2009. PMID: 19828817 Free PMC article.

10

Potent amyloidogenicity and pathogenicity of Aβ43.

Saito T, Suemoto T, Brouwers N, Sleegers K, Funamoto S, Mihira N, Matsuba Y, Yamada K, Nilsson P, Takano J, Nishimura M, Iwata N, Van Broeckhoven C, Ihara Y, Saido TC. Saito T, et al. Among authors: funamoto s. Nat Neurosci. 2011 Jul 3;14(8):1023-32. doi: 10.1038/nn.2858. Nat Neurosci. 2011. PMID: 21725313

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