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The Hsp90 machinery facilitates the transport of diphtheria toxin into human cells.
Schuster M, Schnell L, Feigl P, Birkhofer C, Mohr K, Roeder M, Carle S, Langer S, Tippel F, Buchner J, Fischer G, Hausch F, Frick M, Schwan C, Aktories K, Schiene-Fischer C, Barth H. Schuster M, et al. Among authors: frick m. Sci Rep. 2017 Apr 4;7(1):613. doi: 10.1038/s41598-017-00780-x. Sci Rep. 2017. PMID: 28377614 Free PMC article.
Revisiting an old antibiotic: bacitracin neutralizes binary bacterial toxins and protects cells from intoxication.
Schnell L, Felix I, Müller B, Sadi M, von Bank F, Papatheodorou P, Popoff MR, Aktories K, Waltenberger E, Benz R, Weichbrodt C, Fauler M, Frick M, Barth H. Schnell L, et al. Among authors: frick m. FASEB J. 2019 Apr;33(4):5755-5771. doi: 10.1096/fj.201802453R. Epub 2019 Jan 30. FASEB J. 2019. PMID: 30699302
In conclusion, Bac should be discussed as a therapeutic option against infections with medically relevant toxin-producing bacteria, including C. difficile and B. anthracis, because it inhibits bacterial growth and neutralizes the secreted toxins.-Schnell, L., Felix, I., Muller, B …
In conclusion, Bac should be discussed as a therapeutic option against infections with medically relevant toxin-producing bacteria, includin …
Super-resolution microscopy unveils transmembrane domain-mediated internalization of cross-reacting material 197 into diphtheria toxin-resistant mouse J774A.1 cells and primary rat fibroblasts in vitro.
Fellermann M, Wondany F, Carle S, Nemeth J, Sadhanasatish T, Frick M, Barth H, Michaelis J. Fellermann M, et al. Among authors: frick m. Arch Toxicol. 2020 May;94(5):1753-1761. doi: 10.1007/s00204-020-02731-4. Epub 2020 Apr 8. Arch Toxicol. 2020. PMID: 32266418 Free PMC article.
Inhibition of Clostridioides difficile Toxins TcdA and TcdB by Ambroxol.
Heber S, Barthold L, Baier J, Papatheodorou P, Fois G, Frick M, Barth H, Fischer S. Heber S, et al. Among authors: frick m. Front Pharmacol. 2022 Jan 4;12:809595. doi: 10.3389/fphar.2021.809595. eCollection 2021. Front Pharmacol. 2022. PMID: 35058787 Free PMC article.
The Pore-Forming Subunit C2IIa of the Binary Clostridium botulinum C2 Toxin Reduces the Chemotactic Translocation of Human Polymorphonuclear Leukocytes.
Eisele J, Schreiner S, Borho J, Fischer S, Heber S, Endres S, Fellermann M, Wohlgemuth L, Huber-Lang M, Fois G, Fauler M, Frick M, Barth H. Eisele J, et al. Among authors: frick m. Front Pharmacol. 2022 Feb 11;13:810611. doi: 10.3389/fphar.2022.810611. eCollection 2022. Front Pharmacol. 2022. PMID: 35222028 Free PMC article.
816 results