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Novel, Self-Assembling Dimeric Inhibitors of Human β Tryptase.
Giardina SF, Werner DS, Pingle M, Feinberg PB, Foreman KW, Bergstrom DE, Arnold LD, Barany F. Giardina SF, et al. Among authors: foreman kw. J Med Chem. 2020 Mar 26;63(6):3004-3027. doi: 10.1021/acs.jmedchem.9b01689. Epub 2020 Feb 27. J Med Chem. 2020. PMID: 32057241
Target-Directed Self-Assembly of Homodimeric Drugs Against β-Tryptase.
Giardina SF, Werner DS, Pingle M, Foreman KW, Bergstrom DE, Arnold LD, Barany F. Giardina SF, et al. Among authors: foreman kw. ACS Med Chem Lett. 2018 Jul 5;9(8):827-831. doi: 10.1021/acsmedchemlett.8b00204. eCollection 2018 Aug 9. ACS Med Chem Lett. 2018. PMID: 30128075 Free PMC article.
Reversible linkage of two distinct small molecule inhibitors of Myc generates a dimeric inhibitor with improved potency that is active in myc over-expressing cancer cell lines.
Wanner J, Romashko D, Werner DS, May EW, Peng Y, Schulz R, Foreman KW, Russo S, Arnold LD, Pingle M, Bergstrom DE, Barany F, Thomson S. Wanner J, et al. Among authors: foreman kw. PLoS One. 2015 Apr 15;10(4):e0121793. doi: 10.1371/journal.pone.0121793. eCollection 2015. PLoS One. 2015. PMID: 25875098 Free PMC article.
16 results