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Exogenous phosphatidic acid reduces acetaminophen-induced liver injury in mice by activating hepatic interleukin-6 signaling through inter-organ crosstalk.
Clemens MM, Kennon-McGill S, Vazquez JH, Stephens OW, Peterson EA, Johann DJ, Allard FD, Yee EU, McCullough SS, James LP, Finck BN, McGill MR. Clemens MM, et al. Among authors: finck bn. Acta Pharm Sin B. 2021 Dec;11(12):3836-3846. doi: 10.1016/j.apsb.2021.08.024. Epub 2021 Aug 26. Acta Pharm Sin B. 2021. PMID: 35024310 Free PMC article.
Lipin deactivation after acetaminophen overdose causes phosphatidic acid accumulation in liver and plasma in mice and humans and enhances liver regeneration.
Lutkewitte AJ, Schweitzer GG, Kennon-McGill S, Clemens MM, James LP, Jaeschke H, Finck BN, McGill MR. Lutkewitte AJ, et al. Among authors: finck bn. Food Chem Toxicol. 2018 May;115:273-283. doi: 10.1016/j.fct.2018.03.014. Epub 2018 Mar 11. Food Chem Toxicol. 2018. PMID: 29534981 Free PMC article. No abstract available.
Mice with an adipocyte-specific lipin 1 separation-of-function allele reveal unexpected roles for phosphatidic acid in metabolic regulation.
Mitra MS, Chen Z, Ren H, Harris TE, Chambers KT, Hall AM, Nadra K, Klein S, Chrast R, Su X, Morris AJ, Finck BN. Mitra MS, et al. Among authors: finck bn. Proc Natl Acad Sci U S A. 2013 Jan 8;110(2):642-7. doi: 10.1073/pnas.1213493110. Epub 2012 Dec 24. Proc Natl Acad Sci U S A. 2013. PMID: 23267081 Free PMC article.
168 results