Lipin deactivation after acetaminophen overdose causes phosphatidic acid accumulation in liver and plasma in mice and humans and enhances liver regeneration

Food Chem Toxicol. 2018 May:115:273-283. doi: 10.1016/j.fct.2018.03.014. Epub 2018 Mar 11.
No abstract available

MeSH terms

  • Acetaminophen / adverse effects*
  • Acetaminophen / analysis
  • Adult
  • Aged
  • Aged, 80 and over
  • Animals
  • Chemical and Drug Induced Liver Injury / enzymology
  • Chemical and Drug Induced Liver Injury / etiology
  • Chemical and Drug Induced Liver Injury / metabolism
  • Chemical and Drug Induced Liver Injury / physiopathology*
  • Drug Overdose / enzymology
  • Drug Overdose / etiology
  • Drug Overdose / metabolism*
  • Drug Overdose / physiopathology
  • Female
  • Humans
  • Liver / drug effects
  • Liver / enzymology*
  • Liver / metabolism
  • Liver Regeneration*
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Middle Aged
  • Nuclear Proteins / genetics
  • Nuclear Proteins / metabolism*
  • Phosphatidate Phosphatase / genetics
  • Phosphatidate Phosphatase / metabolism*
  • Phosphatidic Acids / blood
  • Phosphatidic Acids / metabolism*
  • TOR Serine-Threonine Kinases / metabolism
  • Young Adult

Substances

  • Nuclear Proteins
  • Phosphatidic Acids
  • Acetaminophen
  • TOR Serine-Threonine Kinases
  • Lpin1 protein, mouse
  • Phosphatidate Phosphatase
  • Lipin 2 protein, mouse