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Genome-wide association study and functional characterization identifies candidate genes for insulin-stimulated glucose uptake.
Williamson A, Norris DM, Yin X, Broadaway KA, Moxley AH, Vadlamudi S, Wilson EP, Jackson AU, Ahuja V, Andersen MK, Arzumanyan Z, Bonnycastle LL, Bornstein SR, Bretschneider MP, Buchanan TA, Chang YC, Chuang LM, Chung RH, Clausen TD, Damm P, Delgado GE, de Mello VD, Dupuis J, Dwivedi OP, Erdos MR, Fernandes Silva L, Frayling TM, Gieger C, Goodarzi MO, Guo X, Gustafsson S, Hakaste L, Hammar U, Hatem G, Herrmann S, Højlund K, Horn K, Hsueh WA, Hung YJ, Hwu CM, Jonsson A, Kårhus LL, Kleber ME, Kovacs P, Lakka TA, Lauzon M, Lee IT, Lindgren CM, Lindström J, Linneberg A, Liu CT, Luan J, Aly DM, Mathiesen E, Moissl AP, Morris AP, Narisu N, Perakakis N, Peters A, Prasad RB, Rodionov RN, Roll K, Rundsten CF, Sarnowski C, Savonen K, Scholz M, Sharma S, Stinson SE, Suleman S, Tan J, Taylor KD, Uusitupa M, Vistisen D, Witte DR, Walther R, Wu P, Xiang AH, Zethelius B; Meta-Analysis of Glucose and Insulin-related Traits Consortium (MAGIC); Ahlqvist E, Bergman RN, Chen YI, Collins FS, Fall T, Florez JC, Fritsche A, Grallert H, Groop L, Hansen T, Koistinen HA, Komulainen P, Laakso M, Lind L, Loeffler M, März W, Meigs JB, Raffel LJ, Rauramaa R, Rotter JI, Schwarz PEH, Stumvoll M, Sundström J, Tönj… See abstract for full author list ➔ Williamson A, et al. Among authors: fazakerley dj. Nat Genet. 2023 Jun;55(6):973-983. doi: 10.1038/s41588-023-01408-9. Epub 2023 Jun 8. Nat Genet. 2023. PMID: 37291194 Free PMC article.
Mitochondrial oxidants, but not respiration, are sensitive to glucose in adipocytes.
Krycer JR, Elkington SD, Diaz-Vegas A, Cooke KC, Burchfield JG, Fisher-Wellman KH, Cooney GJ, Fazakerley DJ, James DE. Krycer JR, et al. Among authors: fazakerley dj. J Biol Chem. 2020 Jan 3;295(1):99-110. doi: 10.1074/jbc.RA119.011695. Epub 2019 Nov 19. J Biol Chem. 2020. PMID: 31744882 Free PMC article.
Trafficking regulator of GLUT4-1 (TRARG1) is a GSK3 substrate.
Duan X, Norris DM, Humphrey SJ, Yang P, Cooke KC, Bultitude WP, Parker BL, Conway OJ, Burchfield JG, Krycer JR, Brodsky FM, James DE, Fazakerley DJ. Duan X, et al. Among authors: fazakerley dj. Biochem J. 2022 Jun 17;479(11):1237-1256. doi: 10.1042/BCJ20220153. Biochem J. 2022. PMID: 35594055 Free PMC article.
A high-content endogenous GLUT4 trafficking assay reveals new aspects of adipocyte biology.
Diaz-Vegas A, Norris DM, Jall-Rogg S, Cooke KC, Conway OJ, Shun-Shion AS, Duan X, Potter M, van Gerwen J, Baird HJ, Humphrey SJ, James DE, Fazakerley DJ, Burchfield JG. Diaz-Vegas A, et al. Among authors: fazakerley dj. Life Sci Alliance. 2022 Oct 25;6(1):e202201585. doi: 10.26508/lsa.202201585. Print 2023 Jan. Life Sci Alliance. 2022. PMID: 36283703 Free PMC article.
Insulin signaling requires glucose to promote lipid anabolism in adipocytes.
Krycer JR, Quek LE, Francis D, Zadoorian A, Weiss FC, Cooke KC, Nelson ME, Diaz-Vegas A, Humphrey SJ, Scalzo R, Hirayama A, Ikeda S, Shoji F, Suzuki K, Huynh K, Giles C, Varney B, Nagarajan SR, Hoy AJ, Soga T, Meikle PJ, Cooney GJ, Fazakerley DJ, James DE. Krycer JR, et al. Among authors: fazakerley dj. J Biol Chem. 2020 Sep 18;295(38):13250-13266. doi: 10.1074/jbc.RA120.014907. Epub 2020 Jul 28. J Biol Chem. 2020. PMID: 32723868 Free PMC article.
71 results