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Kaposi Sarcoma Herpes Virus (KSHV) infection inhibits macrophage formation and survival by counteracting Macrophage Colony-Stimulating Factor (M-CSF)-induced increase of Reactive Oxygen Species (ROS), c-Jun N-terminal kinase (JNK) phosphorylation and autophagy.
Gilardini Montani MS, Falcinelli L, Santarelli R, Romeo MA, Granato M, Faggioni A, Cirone M. Gilardini Montani MS, et al. Among authors: faggioni a. Int J Biochem Cell Biol. 2019 Sep;114:105560. doi: 10.1016/j.biocel.2019.06.008. Epub 2019 Jun 17. Int J Biochem Cell Biol. 2019. PMID: 31220583
HHV-6A infection dysregulates autophagy/UPR interplay increasing beta amyloid production and tau phosphorylation in astrocytoma cells as well as in primary neurons, possible molecular mechanisms linking viral infection to Alzheimer's disease.
Romeo MA, Gilardini Montani MS, Gaeta A, D'Orazi G, Faggioni A, Cirone M. Romeo MA, et al. Among authors: faggioni a. Biochim Biophys Acta Mol Basis Dis. 2020 Mar 1;1866(3):165647. doi: 10.1016/j.bbadis.2019.165647. Epub 2019 Dec 19. Biochim Biophys Acta Mol Basis Dis. 2020. PMID: 31866416 Free article.
KSHV infection skews macrophage polarisation towards M2-like/TAM and activates Ire1 α-XBP1 axis up-regulating pro-tumorigenic cytokine release and PD-L1 expression.
Gilardini Montani MS, Falcinelli L, Santarelli R, Granato M, Romeo MA, Cecere N, Gonnella R, D'Orazi G, Faggioni A, Cirone M. Gilardini Montani MS, et al. Among authors: faggioni a. Br J Cancer. 2020 Jul;123(2):298-306. doi: 10.1038/s41416-020-0872-0. Epub 2020 May 18. Br J Cancer. 2020. PMID: 32418990 Free PMC article.
187 results