Viral Infection and Autophagy Dysregulation: The Case of HHV-6, EBV and KSHV

Maria Anele Romeo; Roberta Santarelli; Maria Saveria Gilardini Montani; Roberta Gonnella; Rossella Benedetti; Alberto Faggioni; Mara Cirone

doi:10.3390/cells9122624

Viral Infection and Autophagy Dysregulation: The Case of HHV-6, EBV and KSHV

Cells. 2020 Dec 7;9(12):2624. doi: 10.3390/cells9122624.

Authors

Maria Anele Romeo^{1

2}, Roberta Santarelli^{1

2}, Maria Saveria Gilardini Montani^{1

2}, Roberta Gonnella^{1

2}, Rossella Benedetti^{1

2}, Alberto Faggioni^{1

2}, Mara Cirone^{1

2}

Affiliations

¹ Department of Experimental Medicine, Sapienza University of Rome, 00161 Rome, Italy.
² Laboratory Affiliated to Istituto Pasteur Italia-Fondazione Cenci Bolognetti, 00161 Rome, Italy.

Abstract

Human Herpes Virus-6 (HHV-6), Epstein-Barr Virus (EBV) and Kaposi Sarcoma Herpes Virus (KSHV) are viruses that share with other member of the Herpesvirus family the capacity to interfere with the autophagic process. In this paper, mainly based on the findings of our laboratory, we describe how, through different mechanisms, these viruses converge in reducing autophagy to impair DC immune function and how, by infecting and dysregulating autophagy in different cell types, they promote the pathologies associated with their infection, from the neurodegenerative diseases such Alzheimer's disease to cancer.

Keywords: AD; DCs; EBV; HHV-6; KSHV; ROS; UPR; autophagy; cancer.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Autophagy*
Herpesviridae Infections / pathology
Herpesvirus 4, Human*
Herpesvirus 6, Human*
Herpesvirus 8, Human*
Humans
Immune System
Macrophages / metabolism
Neoplasms / metabolism
Reactive Oxygen Species
Virus Diseases / pathology*

Substances

Reactive Oxygen Species