Ernst P - Search Results

1

Targeting Menin disrupts the KMT2A/B and polycomb balance to paradoxically activate bivalent genes.

Sparbier CE, Gillespie A, Gomez J, Kumari N, Motazedian A, Chan KL, Bell CC, Gilan O, Chan YC, Popp S, Gough DJ, Eckersley-Maslin MA, Dawson SJ, Lehner PJ, Sutherland KD, Ernst P, McGeehan GM, Lam EYN, Burr ML, Dawson MA. Sparbier CE, et al. Among authors: ernst p. Nat Cell Biol. 2023 Feb;25(2):258-272. doi: 10.1038/s41556-022-01056-x. Epub 2023 Jan 12. Nat Cell Biol. 2023. PMID: 36635503 Free PMC article.

2

Menin is necessary for long term maintenance of meningioma-1 driven leukemia.

Libbrecht C, Xie HM, Kingsley MC, Haladyna JN, Riedel SS, Alikarami F, Lenard A, McGeehan GM, Ernst P, Bernt KM. Libbrecht C, et al. Among authors: ernst p. Leukemia. 2021 May;35(5):1405-1417. doi: 10.1038/s41375-021-01146-z. Epub 2021 Feb 4. Leukemia. 2021. PMID: 33542482 Free PMC article.

3

Kmt2a cooperates with menin to suppress tumorigenesis in mouse pancreatic islets.

Lin W, Francis JM, Li H, Gao X, Pedamallu CS, Ernst P, Meyerson M. Lin W, et al. Among authors: ernst p. Cancer Biol Ther. 2016 Dec;17(12):1274-1281. doi: 10.1080/15384047.2016.1250986. Epub 2016 Nov 1. Cancer Biol Ther. 2016. PMID: 27801610 Free PMC article.

4

Hematopoietic transformation in the absence of MLL1/KMT2A: distinctions in target gene reactivation.

Chen Y, Ernst P. Chen Y, et al. Among authors: ernst p. Cell Cycle. 2019 Jul;18(14):1525-1531. doi: 10.1080/15384101.2019.1618642. Epub 2019 Jun 4. Cell Cycle. 2019. PMID: 31161857 Free PMC article.

5

cdx4 mutants fail to specify blood progenitors and can be rescued by multiple hox genes.

Davidson AJ, Ernst P, Wang Y, Dekens MP, Kingsley PD, Palis J, Korsmeyer SJ, Daley GQ, Zon LI. Davidson AJ, et al. Among authors: ernst p. Nature. 2003 Sep 18;425(6955):300-6. doi: 10.1038/nature01973. Nature. 2003. PMID: 13679919

6

Definitive hematopoiesis requires the mixed-lineage leukemia gene.

Ernst P, Fisher JK, Avery W, Wade S, Foy D, Korsmeyer SJ. Ernst P, et al. Dev Cell. 2004 Mar;6(3):437-43. doi: 10.1016/s1534-5807(04)00061-9. Dev Cell. 2004. PMID: 15030765 Free article.

7

Context, Context, Context: New Gene Programs Linked to Bad Behavior in MLL-AF9-Initiated Leukemia.

Watanabe T, Ernst P. Watanabe T, et al. Among authors: ernst p. Cancer Cell. 2016 Jul 11;30(1):3-5. doi: 10.1016/j.ccell.2016.06.011. Cancer Cell. 2016. PMID: 27411579 Free article.

8

MLL1 is required for PAX7 expression and satellite cell self-renewal in mice.

Addicks GC, Brun CE, Sincennes MC, Saber J, Porter CJ, Francis Stewart A, Ernst P, Rudnicki MA. Addicks GC, et al. Among authors: ernst p. Nat Commun. 2019 Sep 18;10(1):4256. doi: 10.1038/s41467-019-12086-9. Nat Commun. 2019. PMID: 31534153 Free PMC article.

9

MLL1 Promotes IL-7 Responsiveness and Survival during B Cell Differentiation.

Gan T, Li BE, Mishra BP, Jones KL, Ernst P. Gan T, et al. Among authors: ernst p. J Immunol. 2018 Mar 1;200(5):1682-1691. doi: 10.4049/jimmunol.1701572. Epub 2018 Jan 19. J Immunol. 2018. PMID: 29351999 Free PMC article.

10

Distinct pathways affected by menin versus MLL1/MLL2 in MLL-rearranged acute myeloid leukemia.

Chen Y, Jones KL, Anastassiadis K, Kranz A, Stewart AF, Grembecka J, Meyerson M, Ernst P. Chen Y, et al. Among authors: ernst p. Exp Hematol. 2019 Jan;69:37-42. doi: 10.1016/j.exphem.2018.10.001. Epub 2018 Oct 10. Exp Hematol. 2019. PMID: 30315824 Free PMC article.

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