Context, Context, Context: New Gene Programs Linked to Bad Behavior in MLL-AF9-Initiated Leukemia

Tatsuro Watanabe; Patricia Ernst

doi:10.1016/j.ccell.2016.06.011

Context, Context, Context: New Gene Programs Linked to Bad Behavior in MLL-AF9-Initiated Leukemia

Cancer Cell. 2016 Jul 11;30(1):3-5. doi: 10.1016/j.ccell.2016.06.011.

Authors

Tatsuro Watanabe¹, Patricia Ernst²

Affiliations

¹ Division of Hematology, Oncology and Bone Marrow Transplant, Department of Pediatrics, University of Colorado, Denver/Anschutz Medical Campus, 12800 East 19th Avenue, MS #8302, Aurora, CO 80045, USA.
² Division of Hematology, Oncology and Bone Marrow Transplant, Department of Pediatrics, University of Colorado, Denver/Anschutz Medical Campus, 12800 East 19th Avenue, MS #8302, Aurora, CO 80045, USA. Electronic address: patricia.ernst@ucdenver.edu.

PMID: 27411579
DOI: 10.1016/j.ccell.2016.06.011

Abstract

In this issue of Cancer Cell, Stavropoulou et al. report that expression of the MLL-AF9 fusion results in acute myelogenous leukemia (AML) with different behaviors depending on cell context, which leads them to identify a transcriptional signature surprisingly resembling that of the epithelial-to-mesenchymal (EMT) transition, correlating with aggressiveness of disease.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Comment

MeSH terms

Humans
Leukemia, Myeloid, Acute / genetics
Myeloid-Lymphoid Leukemia Protein / genetics*
Oncogene Proteins, Fusion / genetics*

Substances

Oncogene Proteins, Fusion
Myeloid-Lymphoid Leukemia Protein

Abstract

Publication types

MeSH terms

Substances

Grants and funding