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Discovery of (7R)-14-cyclohexyl-7-{[2-(dimethylamino)ethyl](methyl) amino}-7,8-dihydro-6H-indolo[1,2-e][1,5]benzoxazocine-11-carboxylic acid (MK-3281), a potent and orally bioavailable finger-loop inhibitor of the hepatitis C virus NS5B polymerase.
Narjes F, Crescenzi B, Ferrara M, Habermann J, Colarusso S, Ferreira Mdel R, Stansfield I, Mackay AC, Conte I, Ercolani C, Zaramella S, Palumbi MC, Meuleman P, Leroux-Roels G, Giuliano C, Fiore F, Di Marco S, Baiocco P, Koch U, Migliaccio G, Altamura S, Laufer R, De Francesco R, Rowley M. Narjes F, et al. Among authors: ercolani c. J Med Chem. 2011 Jan 13;54(1):289-301. doi: 10.1021/jm1013105. Epub 2010 Dec 8. J Med Chem. 2011. PMID: 21141896
Tetracyclic indole inhibitors of hepatitis C virus NS5B-polymerase.
Stansfield I, Ercolani C, Mackay A, Conte I, Pompei M, Koch U, Gennari N, Giuliano C, Rowley M, Narjes F. Stansfield I, et al. Among authors: ercolani c. Bioorg Med Chem Lett. 2009 Feb 1;19(3):627-32. doi: 10.1016/j.bmcl.2008.12.068. Epub 2008 Dec 24. Bioorg Med Chem Lett. 2009. PMID: 19131244
Equisetum arvense standardized dried extract hinders age-related osteosarcopenia.
Salvadori L, Paiella M, Castiglioni B, Belladonna ML, Manenti T, Ercolani C, Cornioli L, Clemente N, Scircoli A, Sardella R, Tensi L, Astolfi A, Barreca ML, Chiappalupi S, Gentili G, Bosetti M, Sorci G, Filigheddu N, Riuzzi F. Salvadori L, et al. Among authors: ercolani c. Biomed Pharmacother. 2024 May;174:116517. doi: 10.1016/j.biopha.2024.116517. Epub 2024 Apr 3. Biomed Pharmacother. 2024. PMID: 38574619 Free article.
93 results