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TRIM35-mediated degradation of nuclear PKM2 destabilizes GATA4/6 and induces P53 in cardiomyocytes to promote heart failure.
Lorenzana-Carrillo MA, Gopal K, Byrne NJ, Tejay S, Saleme B, Das SK, Zhang Y, Haromy A, Eaton F, Mendiola Pla M, Bowles DE, Dyck JRB, Ussher JR, Michelakis ED, Sutendra G. Lorenzana-Carrillo MA, et al. Among authors: eaton f. Sci Transl Med. 2022 Nov 2;14(669):eabm3565. doi: 10.1126/scitranslmed.abm3565. Epub 2022 Nov 2. Sci Transl Med. 2022. PMID: 36322626
Ketone ester administration improves glycemia in obese mice.
Tabatabaei Dakhili SA, Yang K, Locatelli CAA, Saed CT, Greenwell AA, Chan JSF, Chahade JJ, Scharff J, Al-Imarah S, Eaton F, Crawford PA, Gopal K, Mulvihill EE, Ussher JR. Tabatabaei Dakhili SA, et al. Among authors: eaton f. Am J Physiol Cell Physiol. 2023 Sep 1;325(3):C750-C757. doi: 10.1152/ajpcell.00300.2023. Epub 2023 Aug 14. Am J Physiol Cell Physiol. 2023. PMID: 37575059
Loss of muscle PDH induces lactic acidosis and adaptive anaplerotic compensation via pyruvate-alanine cycling and glutaminolysis.
Gopal K, Abdualkader AM, Li X, Greenwell AA, Karwi QG, Altamimi TR, Saed C, Uddin GM, Darwesh AM, Jamieson KL, Kim R, Eaton F, Seubert JM, Lopaschuk GD, Ussher JR, Al Batran R. Gopal K, et al. Among authors: eaton f. J Biol Chem. 2023 Dec;299(12):105375. doi: 10.1016/j.jbc.2023.105375. Epub 2023 Oct 20. J Biol Chem. 2023. PMID: 37865313 Free PMC article.
Pharmacological Inhibition of Succinyl Coenzyme A:3-Ketoacid Coenzyme A Transferase Alleviates the Progression of Diabetic Cardiomyopathy.
Greenwell AA, Tabatabaei Dakhili SA, Wagg CS, Saed CT, Chan JSF, Yang K, Mangra-Bala IA, Stenlund MJ, Eaton F, Gopal K, Dyck JRB, Lopaschuk GD, Ussher JR. Greenwell AA, et al. Among authors: eaton f. J Am Heart Assoc. 2024 Apr 2;13(7):e032697. doi: 10.1161/JAHA.123.032697. Epub 2024 Mar 27. J Am Heart Assoc. 2024. PMID: 38533954 Free article. No abstract available.
The Antipsychotic Dopamine 2 Receptor Antagonist Diphenylbutylpiperidines Improve Glycemia in Experimental Obesity by Inhibiting Succinyl-CoA:3-Ketoacid CoA Transferase.
Tabatabaei Dakhili SA, Greenwell AA, Yang K, Abou Farraj R, Saed CT, Gopal K, Chan JSF, Chahade JJ, Eaton F, Lee C, Velázquez-Martínez CA, Crawford PA, Glover JNM, Al Batran R, Ussher JR. Tabatabaei Dakhili SA, et al. Among authors: eaton f. Diabetes. 2023 Jan 1;72(1):126-134. doi: 10.2337/db22-0221. Diabetes. 2023. PMID: 36256885
Stimulating myocardial pyruvate dehydrogenase activity fails to alleviate cardiac abnormalities in a mouse model of human Barth syndrome.
Greenwell AA, Tabatabaei Dakhili SA, Gopal K, Saed CT, Chan JSF, Kazungu Mugabo N, Zhabyeyev P, Eaton F, Kruger J, Oudit GY, Ussher JR. Greenwell AA, et al. Among authors: eaton f. Front Cardiovasc Med. 2022 Sep 23;9:997352. doi: 10.3389/fcvm.2022.997352. eCollection 2022. Front Cardiovasc Med. 2022. PMID: 36211560 Free PMC article.
An isoproteic cocoa butter-based ketogenic diet fails to improve glucose homeostasis and promote weight loss in obese mice.
Greenwell AA, Saed CT, Tabatabaei Dakhili SA, Ho KL, Gopal K, Chan JSF, Kaczmar OO, Dyer SA, Eaton F, Lopaschuk GD, Al Batran R, Ussher JR. Greenwell AA, et al. Among authors: eaton f. Am J Physiol Endocrinol Metab. 2022 Jul 1;323(1):E8-E20. doi: 10.1152/ajpendo.00435.2021. Epub 2022 May 16. Am J Physiol Endocrinol Metab. 2022. PMID: 35575232 Free article.
Pulmonary and Neurologic Effects of Mesenchymal Stromal Cell Extracellular Vesicles in a Multifactorial Lung Injury Model.
Lithopoulos MA, Strueby L, O'Reilly M, Zhong S, Möbius MA, Eaton F, Fung M, Hurskainen M, Cyr-Depauw C, Suen C, Xu L, Collins JJP, Vadivel A, Stewart DJ, Burger D, Thébaud B. Lithopoulos MA, et al. Among authors: eaton f. Am J Respir Crit Care Med. 2022 May 15;205(10):1186-1201. doi: 10.1164/rccm.202012-4520OC. Am J Respir Crit Care Med. 2022. PMID: 35286238
90 results