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Development of EHop-016: a small molecule inhibitor of Rac.
Dharmawardhane S, Hernandez E, Vlaar C. Dharmawardhane S, et al. Enzymes. 2013;33 Pt A(Pt A):117-46. doi: 10.1016/B978-0-12-416749-0.00006-3. Epub 2013 Aug 8. Enzymes. 2013. PMID: 25033803 Free PMC article. Review.
Characterization of EHop-016, novel small molecule inhibitor of Rac GTPase.
Montalvo-Ortiz BL, Castillo-Pichardo L, Hernández E, Humphries-Bickley T, De la Mota-Peynado A, Cubano LA, Vlaar CP, Dharmawardhane S. Montalvo-Ortiz BL, et al. Among authors: dharmawardhane s. J Biol Chem. 2012 Apr 13;287(16):13228-38. doi: 10.1074/jbc.M111.334524. Epub 2012 Mar 1. J Biol Chem. 2012. PMID: 22383527 Free PMC article.
The Rac Inhibitor EHop-016 Inhibits Mammary Tumor Growth and Metastasis in a Nude Mouse Model.
Castillo-Pichardo L, Humphries-Bickley T, De La Parra C, Forestier-Roman I, Martinez-Ferrer M, Hernandez E, Vlaar C, Ferrer-Acosta Y, Washington AV, Cubano LA, Rodriguez-Orengo J, Dharmawardhane S. Castillo-Pichardo L, et al. Among authors: dharmawardhane s. Transl Oncol. 2014 Oct 24;7(5):546-55. doi: 10.1016/j.tranon.2014.07.004. eCollection 2014 Oct. Transl Oncol. 2014. PMID: 25389450 Free PMC article.
Efficacy of Rac and Cdc42 Inhibitor MBQ-167 in Triple-negative Breast Cancer.
Cruz-Collazo A, Ruiz-Calderon JF, Picon H, Borrero-Garcia LD, Lopez I, Castillo-Pichardo L, Del Mar Maldonado M, Duconge J, Medina JI, Bayro MJ, Hernández-O'Farrill E, Vlaar CP, Dharmawardhane S. Cruz-Collazo A, et al. Among authors: dharmawardhane s. Mol Cancer Ther. 2021 Dec;20(12):2420-2432. doi: 10.1158/1535-7163.MCT-21-0348. Epub 2021 Oct 4. Mol Cancer Ther. 2021. PMID: 34607932 Free PMC article.
Characterization of a Dual Rac/Cdc42 Inhibitor MBQ-167 in Metastatic Cancer.
Humphries-Bickley T, Castillo-Pichardo L, Hernandez-O'Farrill E, Borrero-Garcia LD, Forestier-Roman I, Gerena Y, Blanco M, Rivera-Robles MJ, Rodriguez-Medina JR, Cubano LA, Vlaar CP, Dharmawardhane S. Humphries-Bickley T, et al. Among authors: dharmawardhane s. Mol Cancer Ther. 2017 May;16(5):805-818. doi: 10.1158/1535-7163.MCT-16-0442. Mol Cancer Ther. 2017. PMID: 28450422 Free PMC article.
65 results