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Antibacterial oxazolidinones possessing a novel C-5 side chain. (5R)-trans-3-[3-Fluoro-4- (1-oxotetrahydrothiopyran-4-yl)phenyl]-2- oxooxazolidine-5-carboxylic acid amide (PF-00422602), a new lead compound.
Poel TJ, Thomas RC, Adams WJ, Aristoff PA, Barbachyn MR, Boyer FE, Brieland J, Brideau R, Brodfuehrer J, Brown AP, Choy AL, Dermyer M, Dority M, Ford CW, Gadwood RC, Hanna D, Hongliang C, Huband MD, Huber C, Kelly R, Kim JY, Martin JP Jr, Pagano PJ, Ross D, Skerlos L, Sulavik MC, Zhu T, Zurenko GE, Prasad JV. Poel TJ, et al. Among authors: dermyer m. J Med Chem. 2007 Nov 29;50(24):5886-9. doi: 10.1021/jm070708p. Epub 2007 Nov 8. J Med Chem. 2007. PMID: 17988109
Synthesis and SAR of novel conformationally-restricted oxazolidinones possessing gram-positive and fastidious gram-negative antibacterial activity. Part 1: Substituted pyrazoles.
Boyer FE, Vara Prasad JV, Choy AL, Chupak L, Dermyer MR, Ding Q, Huband MD, Jiao W, Kaneko T, Khlebnikov V, Kim JY, Lall MS, Maiti SN, Romero K, Wu X. Boyer FE, et al. Among authors: dermyer mr. Bioorg Med Chem Lett. 2007 Aug 15;17(16):4694-8. doi: 10.1016/j.bmcl.2007.05.056. Epub 2007 May 24. Bioorg Med Chem Lett. 2007. PMID: 17590334
Novel nonpeptidic inhibitors of peptide deformylase.
Jayasekera MM, Kendall A, Shammas R, Dermyer M, Tomala M, Shapiro MA, Holler TP. Jayasekera MM, et al. Among authors: dermyer m. Arch Biochem Biophys. 2000 Sep 15;381(2):313-6. doi: 10.1006/abbi.2000.1987. Arch Biochem Biophys. 2000. PMID: 11032420
Preclinical development of a vaccine-based immunotherapy regimen (VBIR) that induces potent and durable T cell responses to tumor-associated self-antigens.
Cho H, Binder J, Weeratna R, Dermyer M, Dai S, Boccia A, Li W, Li S, Jooss K, Merson J, Hollingsworth RE. Cho H, et al. Among authors: dermyer m. Cancer Immunol Immunother. 2023 Feb;72(2):287-300. doi: 10.1007/s00262-022-03245-x. Epub 2022 Jul 13. Cancer Immunol Immunother. 2023. PMID: 35829790 Free PMC article.
Oncolytic Vaccinia Virus Gene Modification and Cytokine Expression Effects on Tumor Infection, Immune Response, and Killing.
Inoue T, Byrne T, Inoue M, Tait ME, Wall P, Wang A, Dermyer MR, Laklai H, Binder JJ, Lees C, Hollingsworth R, Maruri-Avidal L, Kirn DH, McDonald DM. Inoue T, et al. Among authors: dermyer mr. Mol Cancer Ther. 2021 Aug;20(8):1481-1494. doi: 10.1158/1535-7163.MCT-20-0863. Epub 2021 May 27. Mol Cancer Ther. 2021. PMID: 34045231 Free PMC article.