Synthesis and structure-activity studies of novel benzocycloheptanone oxazolidinone antibacterial agents

J V N Vara Prasad; Frederick E Boyer; Lou Chupak; Michael Dermyer; Qizhu Ding; K Gavardinas; Susan E Hagen; Michael D Huband; Wenhua Jiao; Takushi Kaneko; Samarendra N Maiti; Michael Melnick; Karina Romero; M Patterson; Xiujuan Wu

doi:10.1016/j.bmcl.2006.07.064

Synthesis and structure-activity studies of novel benzocycloheptanone oxazolidinone antibacterial agents

Bioorg Med Chem Lett. 2006 Oct 15;16(20):5392-7. doi: 10.1016/j.bmcl.2006.07.064. Epub 2006 Aug 9.

Authors

J V N Vara Prasad¹, Frederick E Boyer, Lou Chupak, Michael Dermyer, Qizhu Ding, K Gavardinas, Susan E Hagen, Michael D Huband, Wenhua Jiao, Takushi Kaneko, Samarendra N Maiti, Michael Melnick, Karina Romero, M Patterson, Xiujuan Wu

Affiliation

¹ Pfizer Global Research and Development, 2800 Plymouth Road, Ann Arbor, MI 48105, USA. Josyula.VaraPrasad@Pfizer.com

PMID: 16901693
DOI: 10.1016/j.bmcl.2006.07.064

Abstract

We describe a novel class of benzocycloheptanone derived oxazolidinone antibacterial agents. The synthesis and antibacterial activities with structure variation is discussed.

MeSH terms

Anti-Bacterial Agents / chemical synthesis*
Anti-Bacterial Agents / chemistry
Anti-Bacterial Agents / pharmacology*
Benzocycloheptenes / chemical synthesis*
Benzocycloheptenes / chemistry
Benzocycloheptenes / pharmacology*
Gram-Negative Bacteria / drug effects
Gram-Positive Bacteria / drug effects
Microbial Sensitivity Tests
Molecular Structure
Oxazolidinones / chemical synthesis*
Oxazolidinones / chemistry
Oxazolidinones / pharmacology*
Structure-Activity Relationship

Substances

Anti-Bacterial Agents
Benzocycloheptenes
Oxazolidinones