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Genetic imputation of kidney transcriptome, proteome and multi-omics illuminates new blood pressure and hypertension targets.
Xu X, Khunsriraksakul C, Eales JM, Rubin S, Scannali D, Saluja S, Talavera D, Markus H, Wang L, Drzal M, Maan A, Lay AC, Prestes PR, Regan J, Diwadkar AR, Denniff M, Rempega G, Ryszawy J, Król R, Dormer JP, Szulinska M, Walczak M, Antczak A, Matías-García PR, Waldenberger M, Woolf AS, Keavney B, Zukowska-Szczechowska E, Wystrychowski W, Zywiec J, Bogdanski P, Danser AHJ, Samani NJ, Guzik TJ, Morris AP, Liu DJ, Charchar FJ; Human Kidney Tissue Resource Study Group; Tomaszewski M. Xu X, et al. Among authors: denniff m. Nat Commun. 2024 Mar 19;15(1):2359. doi: 10.1038/s41467-024-46132-y. Nat Commun. 2024. PMID: 38504097 Free PMC article.
The integrin ligand SVEP1 regulates GPCR-mediated vasoconstriction via integrins α9β1 and α4β1.
Morris GE, Denniff MJ, Karamanavi E, Andrews SA, Kostogrys RB, Bountziouka V, Ghaderi-Najafabadi M, Shamkhi N, McConnell G, Kaiser MA, Carleton L, Schofield C, Kessler T, Rainbow RD, Samani NJ, Webb TR. Morris GE, et al. Among authors: denniff mj. Br J Pharmacol. 2022 Nov;179(21):4958-4973. doi: 10.1111/bph.15921. Epub 2022 Aug 2. Br J Pharmacol. 2022. PMID: 35802072 Free PMC article.
Pilates and telomere dynamics: A 12-month longitudinal study.
Nickels M, Mastana S, Denniff M, Codd V, Akam E. Nickels M, et al. Among authors: denniff m. J Bodyw Mov Ther. 2022 Apr;30:118-124. doi: 10.1016/j.jbmt.2022.02.013. Epub 2022 Feb 6. J Bodyw Mov Ther. 2022. PMID: 35500959 Free article.
Measurement and initial characterization of leukocyte telomere length in 474,074 participants in UK Biobank.
Codd V, Denniff M, Swinfield C, Warner SC, Papakonstantinou M, Sheth S, Nanus DE, Budgeon CA, Musicha C, Bountziouka V, Wang Q, Bramley R, Allara E, Kaptoge S, Stoma S, Jiang T, Butterworth AS, Wood AM, Di Angelantonio E, Thompson JR, Danesh JN, Nelson CP, Samani NJ. Codd V, et al. Among authors: denniff m. Nat Aging. 2022 Feb;2(2):170-179. doi: 10.1038/s43587-021-00166-9. Epub 2022 Feb 17. Nat Aging. 2022. PMID: 37117760
Polygenic basis and biomedical consequences of telomere length variation.
Codd V, Wang Q, Allara E, Musicha C, Kaptoge S, Stoma S, Jiang T, Hamby SE, Braund PS, Bountziouka V, Budgeon CA, Denniff M, Swinfield C, Papakonstantinou M, Sheth S, Nanus DE, Warner SC, Wang M, Khera AV, Eales J, Ouwehand WH, Thompson JR, Di Angelantonio E, Wood AM, Butterworth AS, Danesh JN, Nelson CP, Samani NJ. Codd V, et al. Among authors: denniff m. Nat Genet. 2021 Oct;53(10):1425-1433. doi: 10.1038/s41588-021-00944-6. Epub 2021 Oct 5. Nat Genet. 2021. PMID: 34611362 Free PMC article.
Uncovering genetic mechanisms of hypertension through multi-omic analysis of the kidney.
Eales JM, Jiang X, Xu X, Saluja S, Akbarov A, Cano-Gamez E, McNulty MT, Finan C, Guo H, Wystrychowski W, Szulinska M, Thomas HB, Pramanik S, Chopade S, Prestes PR, Wise I, Evangelou E, Salehi M, Shakanti Y, Ekholm M, Denniff M, Nazgiewicz A, Eichinger F, Godfrey B, Antczak A, Glyda M, Król R, Eyre S, Brown J, Berzuini C, Bowes J, Caulfield M, Zukowska-Szczechowska E, Zywiec J, Bogdanski P, Kretzler M, Woolf AS, Talavera D, Keavney B, Maffia P, Guzik TJ, O'Keefe RT, Trynka G, Samani NJ, Hingorani A, Sampson MG, Morris AP, Charchar FJ, Tomaszewski M. Eales JM, et al. Among authors: denniff m. Nat Genet. 2021 May;53(5):630-637. doi: 10.1038/s41588-021-00835-w. Epub 2021 May 6. Nat Genet. 2021. PMID: 33958779
Telomere length is independently associated with all-cause mortality in chronic heart failure.
Romaine SPR, Denniff M, Codd V, Nath M, Koekemoer A, Anker SD, Cleland JG, Filippatos G, Levin D, Metra M, Mordi IR, Ouwerkerk W, Ter Maaten JM, van Veldhuisen DJ, Zannad F, Ng LL, van der Harst P, Lang CC, Voors AA, Nelson CP, Samani NJ. Romaine SPR, et al. Among authors: denniff m. Heart. 2022 Jan;108(2):124-129. doi: 10.1136/heartjnl-2020-318654. Epub 2021 Mar 31. Heart. 2022. PMID: 33789973 Free article.
Hypertension and renin-angiotensin system blockers are not associated with expression of angiotensin-converting enzyme 2 (ACE2) in the kidney.
Jiang X, Eales JM, Scannali D, Nazgiewicz A, Prestes P, Maier M, Denniff M, Xu X, Saluja S, Cano-Gamez E, Wystrychowski W, Szulinska M, Antczak A, Byars S, Skrypnik D, Glyda M, Król R, Zywiec J, Zukowska-Szczechowska E, Burrell LM, Woolf AS, Greenstein A, Bogdanski P, Keavney B, Morris AP, Heagerty A, Williams B, Harrap SB, Trynka G, Samani NJ, Guzik TJ, Charchar FJ, Tomaszewski M. Jiang X, et al. Among authors: denniff m. Eur Heart J. 2020 Dec 21;41(48):4580-4588. doi: 10.1093/eurheartj/ehaa794. Eur Heart J. 2020. PMID: 33206176 Free PMC article.
45 results