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Structure-guided design of an Hsp90β N-terminal isoform-selective inhibitor.
Khandelwal A, Kent CN, Balch M, Peng S, Mishra SJ, Deng J, Day VW, Liu W, Subramanian C, Cohen M, Holzbeierlein JM, Matts R, Blagg BSJ. Khandelwal A, et al. Among authors: deng j. Nat Commun. 2018 Jan 30;9(1):425. doi: 10.1038/s41467-017-02013-1. Nat Commun. 2018. PMID: 29382832 Free PMC article.
Crystallization of interleukin-18 for structure-based inhibitor design.
Krumm B, Meng X, Xiang Y, Deng J. Krumm B, et al. Among authors: deng j. Acta Crystallogr F Struct Biol Commun. 2015 Jun;71(Pt 6):710-7. doi: 10.1107/S2053230X15006871. Epub 2015 May 20. Acta Crystallogr F Struct Biol Commun. 2015. PMID: 26057800 Free PMC article.
Selective Inhibition of the Hsp90α Isoform.
Mishra SJ, Khandelwal A, Banerjee M, Balch M, Peng S, Davis RE, Merfeld T, Munthali V, Deng J, Matts RL, Blagg BSJ. Mishra SJ, et al. Among authors: deng j. Angew Chem Int Ed Engl. 2021 May 3;60(19):10547-10551. doi: 10.1002/anie.202015422. Epub 2021 Mar 26. Angew Chem Int Ed Engl. 2021. PMID: 33621416 Free PMC article.
Elucidation of novel TRAP1-Selective inhibitors that regulate mitochondrial processes.
Merfeld T, Peng S, Keegan BM, Crowley VM, Brackett CM, Gutierrez A, McCann NR, Reynolds TS, Rhodes MC, Byrd KM, Deng J, Matts RL, Blagg BSJ. Merfeld T, et al. Among authors: deng j. Eur J Med Chem. 2023 Oct 5;258:115531. doi: 10.1016/j.ejmech.2023.115531. Epub 2023 Jun 5. Eur J Med Chem. 2023. PMID: 37307624
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