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The nickel(II) complex of guanidinium phenyl porphyrin, a specific G-quadruplex ligand, targets telomeres and leads to POT1 mislocalization in culture cells.
Sabater L, Nicolau-Travers ML, De Rache A, Prado E, Dejeu J, Bombarde O, Lacroix J, Calsou P, Defrancq E, Mergny JL, Gomez D, Pratviel G. Sabater L, et al. Among authors: de rache a. J Biol Inorg Chem. 2015 Jun;20(4):729-38. doi: 10.1007/s00775-015-1260-8. Epub 2015 Apr 7. J Biol Inorg Chem. 2015. PMID: 25846142
Impact of G-quadruplex structures and intronic polymorphisms rs17878362 and rs1642785 on basal and ionizing radiation-induced expression of alternative p53 transcripts.
Perriaud L, Marcel V, Sagne C, Favaudon V, Guédin A, De Rache A, Guetta C, Hamon F, Teulade-Fichou MP, Hainaut P, Mergny JL, Hall J. Perriaud L, et al. Among authors: de rache a. Carcinogenesis. 2014 Dec;35(12):2706-15. doi: 10.1093/carcin/bgu206. Epub 2014 Sep 30. Carcinogenesis. 2014. PMID: 25269805 Free PMC article.
Interaction of polycationic Ni(II)-salophen complexes with G-quadruplex DNA.
Lecarme L, Prado E, De Rache A, Nicolau-Travers ML, Bonnet R, van Der Heyden A, Philouze C, Gomez D, Mergny JL, Jamet H, Defrancq E, Jarjayes O, Thomas F. Lecarme L, et al. Among authors: de rache a. Inorg Chem. 2014 Dec 1;53(23):12519-31. doi: 10.1021/ic502063r. Epub 2014 Nov 10. Inorg Chem. 2014. PMID: 25383703
Cobalt(III)porphyrin to target G-quadruplex DNA.
Sabater L, Fang PJ, Chang CF, De Rache A, Prado E, Dejeu J, Garofalo A, Lin JH, Mergny JL, Defrancq E, Pratviel G. Sabater L, et al. Among authors: de rache a. Dalton Trans. 2015 Feb 28;44(8):3701-7. doi: 10.1039/c4dt03631j. Dalton Trans. 2015. PMID: 25573281
Harmonization of QSAR Best Practices and Molecular Docking Provides an Efficient Virtual Screening Tool for Discovering New G-Quadruplex Ligands.
Castillo-González D, Mergny JL, De Rache A, Pérez-Machado G, Cabrera-Pérez MA, Nicolotti O, Introcaso A, Mangiatordi GF, Guédin A, Bourdoncle A, Garrigues T, Pallardó F, Cordeiro MN, Paz-Y-Miño C, Tejera E, Borges F, Cruz-Monteagudo M. Castillo-González D, et al. Among authors: de rache a. J Chem Inf Model. 2015 Oct 26;55(10):2094-110. doi: 10.1021/acs.jcim.5b00415. Epub 2015 Sep 18. J Chem Inf Model. 2015. PMID: 26355653
Efficient Inhibition of Telomerase by Nickel-Salophen Complexes.
Lecarme L, Prado E, De Rache A, Nicolau-Travers ML, Gellon G, Dejeu J, Lavergne T, Jamet H, Gomez D, Mergny JL, Defrancq E, Jarjayes O, Thomas F. Lecarme L, et al. Among authors: de rache a. ChemMedChem. 2016 Jun 6;11(11):1133-6. doi: 10.1002/cmdc.201600171. Epub 2016 May 11. ChemMedChem. 2016. PMID: 27166712
Synthesis, Binding Properties, and Differences in Cell Uptake of G-Quadruplex Ligands Based on Carbohydrate Naphthalene Diimide Conjugates.
Arévalo-Ruiz M, Doria F, Belmonte-Reche E, De Rache A, Campos-Salinas J, Lucas R, Falomir E, Carda M, Pérez-Victoria JM, Mergny JL, Freccero M, Morales JC. Arévalo-Ruiz M, et al. Among authors: de rache a. Chemistry. 2017 Feb 10;23(9):2157-2164. doi: 10.1002/chem.201604886. Epub 2017 Jan 16. Chemistry. 2017. PMID: 27925323
16 results