De Paoli A - Search Results

1

Discovery of Potent and Fast-Acting Antimalarial Bis-1,2,4-triazines.

Priebbenow DL, Mathiew M, Shi DH, Harjani JR, Beveridge JG, Chavchich M, Edstein MD, Duffy S, Avery VM, Jacobs RT, Brand S, Shackleford DM, Wang W, Zhong L, Lee G, Tay E, Barker H, Crighton E, White KL, Charman SA, De Paoli A, Creek DJ, Baell JB. Priebbenow DL, et al. Among authors: de paoli a. J Med Chem. 2021 Apr 8;64(7):4150-4162. doi: 10.1021/acs.jmedchem.1c00044. Epub 2021 Mar 24. J Med Chem. 2021. PMID: 33759519

2

Discovery and development of 2-aminobenzimidazoles as potent antimalarials.

Devine SM, Challis MP, Kigotho JK, Siddiqui G, De Paoli A, MacRaild CA, Avery VM, Creek DJ, Norton RS, Scammells PJ. Devine SM, et al. Among authors: de paoli a. Eur J Med Chem. 2021 Oct 5;221:113518. doi: 10.1016/j.ejmech.2021.113518. Epub 2021 May 13. Eur J Med Chem. 2021. PMID: 34058708

3

The Novel bis-1,2,4-Triazine MIPS-0004373 Demonstrates Rapid and Potent Activity against All Blood Stages of the Malaria Parasite.

Ellis KM, Lucantoni L, Chavchich M, Abraham M, De Paoli A, Luth MR, Zeeman AM, Delves MJ, Terán FS, Straschil U, Baum J, Kocken CHM, Ralph SA, Winzeler EA, Avery VM, Edstein MD, Baell JB, Creek DJ. Ellis KM, et al. Among authors: de paoli a. Antimicrob Agents Chemother. 2021 Oct 18;65(11):e0031121. doi: 10.1128/AAC.00311-21. Epub 2021 Aug 30. Antimicrob Agents Chemother. 2021. PMID: 34460304 Free PMC article.

4

Multi-omic Characterization of the Mode of Action of a Potent New Antimalarial Compound, JPC-3210, Against Plasmodium falciparum.

Birrell GW, Challis MP, De Paoli A, Anderson D, Devine SM, Heffernan GD, Jacobus DP, Edstein MD, Siddiqui G, Creek DJ. Birrell GW, et al. Among authors: de paoli a. Mol Cell Proteomics. 2020 Feb;19(2):308-325. doi: 10.1074/mcp.RA119.001797. Epub 2019 Dec 13. Mol Cell Proteomics. 2020. PMID: 31836637 Free PMC article.

5

System-wide biochemical analysis reveals ozonide antimalarials initially act by disrupting Plasmodium falciparum haemoglobin digestion.

Giannangelo C, Siddiqui G, De Paoli A, Anderson BM, Edgington-Mitchell LE, Charman SA, Creek DJ. Giannangelo C, et al. Among authors: de paoli a. PLoS Pathog. 2020 Jun 26;16(6):e1008485. doi: 10.1371/journal.ppat.1008485. eCollection 2020 Jun. PLoS Pathog. 2020. PMID: 32589689 Free PMC article.

6

[No title available]

[No authors listed] [No authors listed] PMID: 33451390

7

Retargeting azithromycin analogues to have dual-modality antimalarial activity.

Burns AL, Sleebs BE, Siddiqui G, De Paoli AE, Anderson D, Liffner B, Harvey R, Beeson JG, Creek DJ, Goodman CD, McFadden GI, Wilson DW. Burns AL, et al. BMC Biol. 2020 Sep 29;18(1):133. doi: 10.1186/s12915-020-00859-4. BMC Biol. 2020. PMID: 32993629 Free PMC article.

8

Ultraviolet/Visible and Near-Infrared Dual Spectroscopic Method for Detection and Quantification of Low-Level Malaria Parasitemia in Whole Blood.

Adegoke JA, De Paoli A, Afara IO, Kochan K, Creek DJ, Heraud P, Wood BR. Adegoke JA, et al. Among authors: de paoli a. Anal Chem. 2021 Oct 5;93(39):13302-13310. doi: 10.1021/acs.analchem.1c02948. Epub 2021 Sep 24. Anal Chem. 2021. PMID: 34558904

9

A new mass spectral library for high-coverage and reproducible analysis of the Plasmodium falciparum-infected red blood cell proteome.

Siddiqui G, De Paoli A, MacRaild CA, Sexton AE, Boulet C, Shah AD, Batty MB, Schittenhelm RB, Carvalho TG, Creek DJ. Siddiqui G, et al. Among authors: de paoli a. Gigascience. 2022 Mar 7;11:giac008. doi: 10.1093/gigascience/giac008. Gigascience. 2022. PMID: 35254426 Free PMC article.

10

Peroxide Antimalarial Drugs Target Redox Homeostasis in Plasmodium falciparum Infected Red Blood Cells.

Siddiqui G, Giannangelo C, De Paoli A, Schuh AK, Heimsch KC, Anderson D, Brown TG, MacRaild CA, Wu J, Wang X, Dong Y, Vennerstrom JL, Becker K, Creek DJ. Siddiqui G, et al. Among authors: de paoli a. ACS Infect Dis. 2022 Jan 14;8(1):210-226. doi: 10.1021/acsinfecdis.1c00550. Epub 2022 Jan 5. ACS Infect Dis. 2022. PMID: 34985858 Free PMC article.

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