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Nucleoside optimization for RNAi: a high-throughput platform.
Butora G, Kenski DM, Cooper AJ, Fu W, Qi N, Li JJ, Flanagan WM, Davies IW. Butora G, et al. Among authors: davies iw. J Am Chem Soc. 2011 Oct 26;133(42):16766-9. doi: 10.1021/ja2068774. Epub 2011 Sep 30. J Am Chem Soc. 2011. PMID: 21942264
siRNA-optimized Modifications for Enhanced In Vivo Activity.
Kenski DM, Butora G, Willingham AT, Cooper AJ, Fu W, Qi N, Soriano F, Davies IW, Flanagan WM. Kenski DM, et al. Among authors: davies iw. Mol Ther Nucleic Acids. 2012 Jan 24;1(1):e5. doi: 10.1038/mtna.2011.4. Mol Ther Nucleic Acids. 2012. PMID: 23344622 Free PMC article.
Improving the in vivo therapeutic index of siRNA polymer conjugates through increasing pH responsiveness.
Guidry EN, Farand J, Soheili A, Parish CA, Kevin NJ, Pipik B, Calati KB, Ikemoto N, Waldman JH, Latham AH, Howell BJ, Leone A, Garbaccio RM, Barrett SE, Parmar RG, Truong QT, Mao B, Davies IW, Colletti SL, Sepp-Lorenzino L. Guidry EN, et al. Among authors: davies iw. Bioconjug Chem. 2014 Feb 19;25(2):296-307. doi: 10.1021/bc400442p. Epub 2014 Jan 10. Bioconjug Chem. 2014. PMID: 24409989
Cyclic-disulfide-based prodrugs for cytosol-specific drug delivery.
Butora G, Qi N, Fu W, Nguyen T, Huang HC, Davies IW. Butora G, et al. Among authors: davies iw. Angew Chem Int Ed Engl. 2014 Dec 15;53(51):14046-50. doi: 10.1002/anie.201407130. Epub 2014 Oct 24. Angew Chem Int Ed Engl. 2014. PMID: 25346363
A multifunctional catalyst that stereoselectively assembles prodrugs.
DiRocco DA, Ji Y, Sherer EC, Klapars A, Reibarkh M, Dropinski J, Mathew R, Maligres P, Hyde AM, Limanto J, Brunskill A, Ruck RT, Campeau LC, Davies IW. DiRocco DA, et al. Among authors: davies iw. Science. 2017 Apr 28;356(6336):426-430. doi: 10.1126/science.aam7936. Science. 2017. PMID: 28450641
125 results