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TP63, SOX2, and KLF5 Establish a Core Regulatory Circuitry That Controls Epigenetic and Transcription Patterns in Esophageal Squamous Cell Carcinoma Cell Lines.
Jiang YY, Jiang Y, Li CQ, Zhang Y, Dakle P, Kaur H, Deng JW, Lin RY, Han L, Xie JJ, Yan Y, Doan N, Zheng Y, Mayakonda A, Hazawa M, Xu L, Li Y, Aswad L, Jeitany M, Kanojia D, Guan XY, Said JW, Yang W, Fullwood MJ, Lin DC, Koeffler HP. Jiang YY, et al. Among authors: dakle p. Gastroenterology. 2020 Oct;159(4):1311-1327.e19. doi: 10.1053/j.gastro.2020.06.050. Epub 2020 Jun 30. Gastroenterology. 2020. PMID: 32619460
CARD10, a CEBPE target involved in granulocytic differentiation.
Shyamsunder P, Sankar H, Mayakonda A, Han L, Nordin HBM, Woon TW, Shanmugasundaram M, Dakle P, Madan V, Koeffler HP. Shyamsunder P, et al. Among authors: dakle p. Haematologica. 2018 Aug;103(8):1269-1277. doi: 10.3324/haematol.2018.190280. Epub 2018 May 17. Haematologica. 2018. PMID: 29773596 Free PMC article.
ASXL2 regulates hematopoiesis in mice and its deficiency promotes myeloid expansion.
Madan V, Han L, Hattori N, Teoh WW, Mayakonda A, Sun QY, Ding LW, Nordin HBM, Lim SL, Shyamsunder P, Dakle P, Sundaresan J, Doan NB, Sanada M, Sato-Otsubo A, Meggendorfer M, Yang H, Said JW, Ogawa S, Haferlach T, Liang DC, Shih LY, Nakamaki T, Wang QT, Koeffler HP. Madan V, et al. Among authors: dakle p. Haematologica. 2018 Dec;103(12):1980-1990. doi: 10.3324/haematol.2018.189928. Epub 2018 Aug 9. Haematologica. 2018. PMID: 30093396 Free PMC article.
Bromodomain and extraterminal proteins foster the core transcriptional regulatory programs and confer vulnerability in liposarcoma.
Chen Y, Xu L, Mayakonda A, Huang ML, Kanojia D, Tan TZ, Dakle P, Lin RY, Ke XY, Said JW, Chen J, Gery S, Ding LW, Jiang YY, Pang A, Puhaindran ME, Goh BC, Koeffler HP. Chen Y, et al. Among authors: dakle p. Nat Commun. 2019 Mar 22;10(1):1353. doi: 10.1038/s41467-019-09257-z. Nat Commun. 2019. PMID: 30903020 Free PMC article.
Identification of a novel enhancer of CEBPE essential for granulocytic differentiation.
Shyamsunder P, Shanmugasundaram M, Mayakonda A, Dakle P, Teoh WW, Han L, Kanojia D, Lim MC, Fullwood M, An O, Yang H, Shi J, Hossain MZ, Madan V, Koeffler HP. Shyamsunder P, et al. Among authors: dakle p. Blood. 2019 Jun 6;133(23):2507-2517. doi: 10.1182/blood.2018886077. Epub 2019 Apr 5. Blood. 2019. PMID: 30952671 Free article.
RNA-Binding Protein ZFP36L1 Suppresses Hypoxia and Cell-Cycle Signaling.
Loh XY, Sun QY, Ding LW, Mayakonda A, Venkatachalam N, Yeo MS, Silva TC, Xiao JF, Doan NB, Said JW, Ran XB, Zhou SQ, Dakle P, Shyamsunder P, Koh AP, Huang RY, Berman BP, Tan SY, Yang H, Lin DC, Koeffler HP. Loh XY, et al. Among authors: dakle p. Cancer Res. 2020 Jan 15;80(2):219-233. doi: 10.1158/0008-5472.CAN-18-2796. Epub 2019 Sep 24. Cancer Res. 2020. PMID: 31551365
MNK1 and MNK2 enforce expression of E2F1, FOXM1, and WEE1 to drive soft tissue sarcoma.
Ke XY, Chen Y, Tham VY, Lin RY, Dakle P, Nacro K, Puhaindran ME, Houghton P, Pang A, Lee VK, Ding LW, Gery S, Hill J, Chen L, Xu L, Koeffler HP. Ke XY, et al. Among authors: dakle p. Oncogene. 2021 Mar;40(10):1851-1867. doi: 10.1038/s41388-021-01661-4. Epub 2021 Feb 9. Oncogene. 2021. PMID: 33564073 Free PMC article.
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