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C/EBPβ is a MYB- and p300-cooperating pro-leukemogenic factor and promising drug target in acute myeloid leukemia.
Yusenko MV, Trentmann A, Casolari DA, Abdel Ghani L, Lenz M, Horn M, Dörner W, Klempnauer S, Mootz HD, Arteaga MF, Mikesch JH, D'Andrea RJ, Gonda TJ, Müller-Tidow C, Schmidt TJ, Klempnauer KH. Yusenko MV, et al. Among authors: dorner w. Oncogene. 2021 Jul;40(29):4746-4758. doi: 10.1038/s41388-021-01800-x. Epub 2021 May 6. Oncogene. 2021. PMID: 33958723 Free PMC article.
Withaferin A, a natural compound with anti-tumor activity, is a potent inhibitor of transcription factor C/EBPβ.
Falkenberg KD, Jakobs A, Matern JC, Dörner W, Uttarkar S, Trentmann A, Steinmann S, Coulibaly A, Schomburg C, Mootz HD, Schmidt TJ, Klempnauer KH. Falkenberg KD, et al. Among authors: dorner w. Biochim Biophys Acta Mol Cell Res. 2017 Jul;1864(7):1349-1358. doi: 10.1016/j.bbamcr.2017.05.003. Epub 2017 May 2. Biochim Biophys Acta Mol Cell Res. 2017. PMID: 28476645 Free article.
Bridging of membrane surfaces by annexin A2.
Grill D, Matos ALL, de Vries WC, Kudruk S, Heflik M, Dörner W, Mootz HD, Jan Ravoo B, Galla HJ, Gerke V. Grill D, et al. Among authors: dorner w. Sci Rep. 2018 Oct 2;8(1):14662. doi: 10.1038/s41598-018-33044-3. Sci Rep. 2018. PMID: 30279443 Free PMC article.
Photobodies: Light-Activatable Single-Domain Antibody Fragments.
Jedlitzke B, Yilmaz Z, Dörner W, Mootz HD. Jedlitzke B, et al. Among authors: dorner w. Angew Chem Int Ed Engl. 2020 Jan 20;59(4):1506-1510. doi: 10.1002/anie.201912286. Epub 2019 Dec 12. Angew Chem Int Ed Engl. 2020. PMID: 31755215 Free PMC article.
52 results