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Isololiolide, a carotenoid metabolite isolated from the brown alga Cystoseira tamariscifolia, is cytotoxic and able to induce apoptosis in hepatocarcinoma cells through caspase-3 activation, decreased Bcl-2 levels, increased p53 expression and PARP cleavage.
Vizetto-Duarte C, Custódio L, Gangadhar KN, Lago JH, Dias C, Matos AM, Neng N, Nogueira JM, Barreira L, Albericio F, Rauter AP, Varela J. Vizetto-Duarte C, et al. Among authors: custodio l. Phytomedicine. 2016 May 15;23(5):550-7. doi: 10.1016/j.phymed.2016.02.008. Epub 2016 Feb 26. Phytomedicine. 2016. PMID: 27064014 Free article.
Nutritional anti-nutritional chemical composition and antioxidant activities of the leaves of the sea cliff dwelling species Limonium spathulatum (Desf.) Kuntze.
Youssef S, Custódio L, Rodrigues MJ, Pereira CG, Calhelha RC, Pinela J, Barros L, Jekő J, Cziáky Z, Ben Hamed K. Youssef S, et al. Among authors: custodio l. Front Plant Sci. 2022 Nov 15;13:979343. doi: 10.3389/fpls.2022.979343. eCollection 2022. Front Plant Sci. 2022. PMID: 36466224 Free PMC article.
116 results