Crabtree MD - Search Results

1

Insights into Coupled Folding and Binding Mechanisms from Kinetic Studies.

Shammas SL, Crabtree MD, Dahal L, Wicky BI, Clarke J. Shammas SL, et al. Among authors: crabtree md. J Biol Chem. 2016 Mar 25;291(13):6689-95. doi: 10.1074/jbc.R115.692715. Epub 2016 Feb 5. J Biol Chem. 2016. PMID: 26851275 Free PMC article. Review.

2

GADIS: Algorithm for designing sequences to achieve target secondary structure profiles of intrinsically disordered proteins.

Harmon TS, Crabtree MD, Shammas SL, Posey AE, Clarke J, Pappu RV. Harmon TS, et al. Among authors: crabtree md. Protein Eng Des Sel. 2016 Sep;29(9):339-46. doi: 10.1093/protein/gzw034. Epub 2016 Aug 8. Protein Eng Des Sel. 2016. PMID: 27503953 Free PMC article.

3

Folding and binding pathways of BH3-only proteins are encoded within their intrinsically disordered sequence, not templated by partner proteins.

Crabtree MD, Mendonça CATF, Bubb QR, Clarke J. Crabtree MD, et al. J Biol Chem. 2018 Jun 22;293(25):9718-9723. doi: 10.1074/jbc.RA118.002791. Epub 2018 May 1. J Biol Chem. 2018. PMID: 29716994 Free PMC article.

4

Stopped-Flow Kinetic Techniques for Studying Binding Reactions of Intrinsically Disordered Proteins.

Crabtree MD, Shammas SL. Crabtree MD, et al. Methods Enzymol. 2018;611:423-457. doi: 10.1016/bs.mie.2018.09.026. Epub 2018 Nov 7. Methods Enzymol. 2018. PMID: 30471695

5

Conserved Helix-Flanking Prolines Modulate Intrinsically Disordered Protein:Target Affinity by Altering the Lifetime of the Bound Complex.

Crabtree MD, Borcherds W, Poosapati A, Shammas SL, Daughdrill GW, Clarke J. Crabtree MD, et al. Biochemistry. 2017 May 9;56(18):2379-2384. doi: 10.1021/acs.biochem.7b00179. Epub 2017 Apr 26. Biochemistry. 2017. PMID: 28425697 Free PMC article.

6

Protein-peptide association kinetics beyond the seconds timescale from atomistic simulations.

Paul F, Wehmeyer C, Abualrous ET, Wu H, Crabtree MD, Schöneberg J, Clarke J, Freund C, Weikl TR, Noé F. Paul F, et al. Among authors: crabtree md. Nat Commun. 2017 Oct 23;8(1):1095. doi: 10.1038/s41467-017-01163-6. Nat Commun. 2017. PMID: 29062047 Free PMC article.

7

Author Correction: Protein-peptide association kinetics beyond the seconds timescale from atomistic simulations.

Paul F, Wehmeyer C, Abualrous ET, Wu H, Crabtree MD, Schöneberg J, Clarke J, Freund C, Weikl TR, Noé F. Paul F, et al. Among authors: crabtree md. Nat Commun. 2018 Mar 9;9(1):1073. doi: 10.1038/s41467-018-03452-0. Nat Commun. 2018. PMID: 29523780 Free PMC article.

8

Thermodynamic mapping of effector protein interfaces with RalA and RalB.

Campbell LJ, Peppa M, Crabtree MD, Shafiq A, McGough NF, Mott HR, Owen D. Campbell LJ, et al. Among authors: crabtree md. Biochemistry. 2015 Feb 17;54(6):1380-9. doi: 10.1021/bi501530u. Epub 2015 Feb 5. Biochemistry. 2015. PMID: 25621740 Free article.

9

In Vitro Transition Temperature Measurement of Phase-Separating Proteins by Microscopy.

Holland J, Crabtree MD, Nott TJ. Holland J, et al. Among authors: crabtree md. Methods Mol Biol. 2020;2141:703-714. doi: 10.1007/978-1-0716-0524-0_36. Methods Mol Biol. 2020. PMID: 32696385

10

Bitopic Binding Mode of an M₁ Muscarinic Acetylcholine Receptor Agonist Associated with Adverse Clinical Trial Outcomes.

Bradley SJ, Molloy C, Bundgaard C, Mogg AJ, Thompson KJ, Dwomoh L, Sanger HE, Crabtree MD, Brooke SM, Sexton PM, Felder CC, Christopoulos A, Broad LM, Tobin AB, Langmead CJ. Bradley SJ, et al. Among authors: crabtree md. Mol Pharmacol. 2018 Jun;93(6):645-656. doi: 10.1124/mol.118.111872. Epub 2018 Apr 25. Mol Pharmacol. 2018. PMID: 29695609 Free PMC article.

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