Cooper LJN - Search Results

1

Regulated intratumoral expression of IL-12 using a RheoSwitch Therapeutic System^® (RTS^®) gene switch as gene therapy for the treatment of glioma.

Barrett JA, Cai H, Miao J, Khare PD, Gonzalez P, Dalsing-Hernandez J, Sharma G, Chan T, Cooper LJN, Lebel F. Barrett JA, et al. Among authors: cooper ljn. Cancer Gene Ther. 2018 Jun;25(5-6):106-116. doi: 10.1038/s41417-018-0019-0. Epub 2018 May 14. Cancer Gene Ther. 2018. PMID: 29755109 Free PMC article.

2

Regulatable interleukin-12 gene therapy in patients with recurrent high-grade glioma: Results of a phase 1 trial.

Chiocca EA, Yu JS, Lukas RV, Solomon IH, Ligon KL, Nakashima H, Triggs DA, Reardon DA, Wen P, Stopa BM, Naik A, Rudnick J, Hu JL, Kumthekar P, Yamini B, Buck JY, Demars N, Barrett JA, Gelb AB, Zhou J, Lebel F, Cooper LJN. Chiocca EA, et al. Among authors: cooper ljn. Sci Transl Med. 2019 Aug 14;11(505):eaaw5680. doi: 10.1126/scitranslmed.aaw5680. Sci Transl Med. 2019. PMID: 31413142 Free PMC article. Clinical Trial.

3

Combined immunotherapy with controlled interleukin-12 gene therapy and immune checkpoint blockade in recurrent glioblastoma: An open-label, multi-institutional phase I trial.

Chiocca EA, Gelb AB, Chen CC, Rao G, Reardon DA, Wen PY, Bi WL, Peruzzi P, Amidei C, Triggs D, Seften L, Park G, Grant J, Truman K, Buck JY, Hadar N, Demars N, Miao J, Estupinan T, Loewy J, Chadha K, Tringali J, Cooper L, Lukas RV. Chiocca EA, et al. Neuro Oncol. 2022 Jun 1;24(6):951-963. doi: 10.1093/neuonc/noab271. Neuro Oncol. 2022. PMID: 34850166 Free PMC article. Clinical Trial.

4

Translational Implications for Off-the-shelf Immune Cells Expressing Chimeric Antigen Receptors.

Torikai H, Cooper LJ. Torikai H, et al. Mol Ther. 2016 Aug;24(7):1178-86. doi: 10.1038/mt.2016.106. Epub 2016 May 16. Mol Ther. 2016. PMID: 27203439 Free PMC article. Review.

5

Moving from tinkering in the garage to assembly line production: the manufacture of genetically modified T cells expressing chimeric antigen receptors (CARs) comes on line.

Cooper LJ. Cooper LJ. Cancer Gene Ther. 2015 Mar;22(2):64-6. doi: 10.1038/cgt.2014.70. Epub 2015 Feb 13. Cancer Gene Ther. 2015. PMID: 25675874 Review. No abstract available.

6

Antitumor activity of CD56-chimeric antigen receptor T cells in neuroblastoma and SCLC models.

Crossland DL, Denning WL, Ang S, Olivares S, Mi T, Switzer K, Singh H, Huls H, Gold KS, Glisson BS, Cooper LJ, Heymach JV. Crossland DL, et al. Oncogene. 2018 Jul;37(27):3686-3697. doi: 10.1038/s41388-018-0187-2. Epub 2018 Apr 6. Oncogene. 2018. PMID: 29622795

7

The hyperactive Sleeping Beauty transposase SB100X improves the genetic modification of T cells to express a chimeric antigen receptor.

Jin Z, Maiti S, Huls H, Singh H, Olivares S, Mátés L, Izsvák Z, Ivics Z, Lee DA, Champlin RE, Cooper LJ. Jin Z, et al. Gene Ther. 2011 Sep;18(9):849-56. doi: 10.1038/gt.2011.40. Epub 2011 Mar 31. Gene Ther. 2011. PMID: 21451576 Free PMC article.

8

Tethered IL-15 augments antitumor activity and promotes a stem-cell memory subset in tumor-specific T cells.

Hurton LV, Singh H, Najjar AM, Switzer KC, Mi T, Maiti S, Olivares S, Rabinovich B, Huls H, Forget MA, Datar V, Kebriaei P, Lee DA, Champlin RE, Cooper LJ. Hurton LV, et al. Proc Natl Acad Sci U S A. 2016 Nov 29;113(48):E7788-E7797. doi: 10.1073/pnas.1610544113. Epub 2016 Nov 14. Proc Natl Acad Sci U S A. 2016. PMID: 27849617 Free PMC article.

9

Preclinical Efficacy and Safety of CD19CAR Cytokine-Induced Killer Cells Transfected with Sleeping Beauty Transposon for the Treatment of Acute Lymphoblastic Leukemia.

Magnani CF, Mezzanotte C, Cappuzzello C, Bardini M, Tettamanti S, Fazio G, Cooper LJN, Dastoli G, Cazzaniga G, Biondi A, Biagi E. Magnani CF, et al. Among authors: cooper ljn. Hum Gene Ther. 2018 May;29(5):602-613. doi: 10.1089/hum.2017.207. Epub 2018 Apr 16. Hum Gene Ther. 2018. PMID: 29641322

10

piggyBac transposon/transposase system to generate CD19-specific T cells for the treatment of B-lineage malignancies.

Manuri PV, Wilson MH, Maiti SN, Mi T, Singh H, Olivares S, Dawson MJ, Huls H, Lee DA, Rao PH, Kaminski JM, Nakazawa Y, Gottschalk S, Kebriaei P, Shpall EJ, Champlin RE, Cooper LJ. Manuri PV, et al. Hum Gene Ther. 2010 Apr;21(4):427-37. doi: 10.1089/hum.2009.114. Hum Gene Ther. 2010. PMID: 19905893 Free PMC article.

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