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Inhibition of 7-dehydrocholesterol reductase prevents hepatic ferroptosis under an active state of sterol synthesis.
Yamada N, Karasawa T, Ito J, Yamamuro D, Morimoto K, Nakamura T, Komada T, Baatarjav C, Saimoto Y, Jinnouchi Y, Watanabe K, Miura K, Yahagi N, Nakagawa K, Matsumura T, Yamada KI, Ishibashi S, Sata N, Conrad M, Takahashi M. Yamada N, et al. Among authors: conrad m. Nat Commun. 2024 Mar 12;15(1):2195. doi: 10.1038/s41467-024-46386-6. Nat Commun. 2024. PMID: 38472233 Free PMC article.
Ferroptotic cell death triggered by conjugated linolenic acids is mediated by ACSL1.
Beatty A, Singh T, Tyurina YY, Tyurin VA, Samovich S, Nicolas E, Maslar K, Zhou Y, Cai KQ, Tan Y, Doll S, Conrad M, Subramanian A, Bayır H, Kagan VE, Rennefahrt U, Peterson JR. Beatty A, et al. Among authors: conrad m. Nat Commun. 2021 Apr 14;12(1):2244. doi: 10.1038/s41467-021-22471-y. Nat Commun. 2021. PMID: 33854057 Free PMC article.
Dysfunction of the key ferroptosis-surveilling systems hypersensitizes mice to tubular necrosis during acute kidney injury.
Tonnus W, Meyer C, Steinebach C, Belavgeni A, von Mässenhausen A, Gonzalez NZ, Maremonti F, Gembardt F, Himmerkus N, Latk M, Locke S, Marschner J, Li W, Short S, Doll S, Ingold I, Proneth B, Daniel C, Kabgani N, Kramann R, Motika S, Hergenrother PJ, Bornstein SR, Hugo C, Becker JU, Amann K, Anders HJ, Kreisel D, Pratt D, Gütschow M, Conrad M, Linkermann A. Tonnus W, et al. Among authors: conrad m. Nat Commun. 2021 Jul 20;12(1):4402. doi: 10.1038/s41467-021-24712-6. Nat Commun. 2021. PMID: 34285231 Free PMC article.
Targeting ferroptosis protects against experimental (multi)organ dysfunction and death.
Van Coillie S, Van San E, Goetschalckx I, Wiernicki B, Mukhopadhyay B, Tonnus W, Choi SM, Roelandt R, Dumitrascu C, Lamberts L, Dams G, Weyts W, Huysentruyt J, Hassannia B, Ingold I, Lele S, Meyer E, Berg M, Seurinck R, Saeys Y, Vermeulen A, van Nuijs ALN, Conrad M, Linkermann A, Rajapurkar M, Vandenabeele P, Hoste E, Augustyns K, Vanden Berghe T. Van Coillie S, et al. Among authors: conrad m. Nat Commun. 2022 Feb 24;13(1):1046. doi: 10.1038/s41467-022-28718-6. Nat Commun. 2022. PMID: 35210435 Free PMC article.
Nutritional and Metabolic Control of Ferroptosis.
Mishima E, Conrad M. Mishima E, et al. Among authors: conrad m. Annu Rev Nutr. 2022 Aug 22;42:275-309. doi: 10.1146/annurev-nutr-062320-114541. Epub 2022 Jun 1. Annu Rev Nutr. 2022. PMID: 35650671 Review.
A non-canonical vitamin K cycle is a potent ferroptosis suppressor.
Mishima E, Ito J, Wu Z, Nakamura T, Wahida A, Doll S, Tonnus W, Nepachalovich P, Eggenhofer E, Aldrovandi M, Henkelmann B, Yamada KI, Wanninger J, Zilka O, Sato E, Feederle R, Hass D, Maida A, Mourão ASD, Linkermann A, Geissler EK, Nakagawa K, Abe T, Fedorova M, Proneth B, Pratt DA, Conrad M. Mishima E, et al. Among authors: conrad m. Nature. 2022 Aug;608(7924):778-783. doi: 10.1038/s41586-022-05022-3. Epub 2022 Aug 3. Nature. 2022. PMID: 35922516 Free PMC article.
Nonmetabolic role for CKB in ferroptosis.
Mishima E, Conrad M. Mishima E, et al. Among authors: conrad m. Nat Cell Biol. 2023 May;25(5):633-634. doi: 10.1038/s41556-023-01104-0. Nat Cell Biol. 2023. PMID: 37156911 No abstract available.
Phase separation of FSP1 promotes ferroptosis.
Nakamura T, Hipp C, Santos Dias Mourão A, Borggräfe J, Aldrovandi M, Henkelmann B, Wanninger J, Mishima E, Lytton E, Emler D, Proneth B, Sattler M, Conrad M. Nakamura T, et al. Among authors: conrad m. Nature. 2023 Jul;619(7969):371-377. doi: 10.1038/s41586-023-06255-6. Epub 2023 Jun 28. Nature. 2023. PMID: 37380771 Free PMC article.
DHODH inhibitors sensitize to ferroptosis by FSP1 inhibition.
Mishima E, Nakamura T, Zheng J, Zhang W, Mourão ASD, Sennhenn P, Conrad M. Mishima E, et al. Among authors: conrad m. Nature. 2023 Jul;619(7968):E9-E18. doi: 10.1038/s41586-023-06269-0. Epub 2023 Jul 5. Nature. 2023. PMID: 37407687 No abstract available.
1,306 results