DHODH inhibitors sensitize to ferroptosis by FSP1 inhibition

Nature. 2023 Jul;619(7968):E9-E18. doi: 10.1038/s41586-023-06269-0. Epub 2023 Jul 5.

Authors

Eikan Mishima^#^{1

2}, Toshitaka Nakamura^#¹, Jiashuo Zheng^#¹, Weijia Zhang¹, André Santos Dias Mourão³, Peter Sennhenn⁴, Marcus Conrad⁵

Affiliations

¹ Institute of Metabolism and Cell Death, Helmholtz Zentrum München, Neuherberg, Germany.
² Division of Nephrology, Rheumatology and Endocrinology, Tohoku University Graduate School of Medicine, Sendai, Japan.
³ Institute of Structural Biology, Helmholtz Zentrum München, Neuherberg, Germany.
⁴ transMedChem, Munich, Germany.
⁵ Institute of Metabolism and Cell Death, Helmholtz Zentrum München, Neuherberg, Germany. marcus.conrad@helmholtz-munich.de.

^# Contributed equally.

PMID: 37407687
DOI: 10.1038/s41586-023-06269-0

No abstract available

Publication types

Letter
Comment

MeSH terms

Dihydroorotate Dehydrogenase
Ferroptosis*
Humans
Neoplasms*

Substances

Dihydroorotate Dehydrogenase