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821 results

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Druggable growth dependencies and tumor evolution analysis in patient-derived organoids of neuroendocrine neoplasms from multiple body sites.
Dayton TL, Alcala N, Moonen L, den Hartigh L, Geurts V, Mangiante L, Lap L, Dost AFM, Beumer J, Levy S, van Leeuwaarde RS, Hackeng WM, Samsom K, Voegele C, Sexton-Oates A, Begthel H, Korving J, Hillen L, Brosens LAA, Lantuejoul S, Jaksani S, Kok NFM, Hartemink KJ, Klomp HM, Borel Rinkes IHM, Dingemans AM, Valk GD, Vriens MR, Buikhuisen W, van den Berg J, Tesselaar M, Derks J, Speel EJ, Foll M, Fernández-Cuesta L, Clevers H. Dayton TL, et al. Among authors: clevers h. Cancer Cell. 2023 Dec 11;41(12):2083-2099.e9. doi: 10.1016/j.ccell.2023.11.007. Cancer Cell. 2023. PMID: 38086335 Free article.
Drug-repurposing screen on patient-derived organoids identifies therapy-induced vulnerability in KRAS-mutant colon cancer.
Mertens S, Huismans MA, Verissimo CS, Ponsioen B, Overmeer R, Proost N, van Tellingen O, van de Ven M, Begthel H, Boj SF, Clevers H, Roodhart JML, Bos JL, Snippert HJG. Mertens S, et al. Among authors: clevers h. Cell Rep. 2023 Apr 25;42(4):112324. doi: 10.1016/j.celrep.2023.112324. Epub 2023 Mar 30. Cell Rep. 2023. PMID: 37000626 Free article.
Patient-derived head and neck cancer organoids allow treatment stratification and serve as a tool for biomarker validation and identification.
Millen R, De Kort WWB, Koomen M, van Son GJF, Gobits R, Penning de Vries B, Begthel H, Zandvliet M, Doornaert P, Raaijmakers CPJ, Geurts MH, Elias SG, van Es RJJ, de Bree R, Devriese LA, Willems SM, Kranenburg O, Driehuis E, Clevers H. Millen R, et al. Among authors: clevers h. Med. 2023 May 12;4(5):290-310.e12. doi: 10.1016/j.medj.2023.04.003. Med. 2023. PMID: 37178682 Free article.
Hallmarks of stemness in mammalian tissues.
Beumer J, Clevers H. Beumer J, et al. Among authors: clevers h. Cell Stem Cell. 2024 Jan 4;31(1):7-24. doi: 10.1016/j.stem.2023.12.006. Cell Stem Cell. 2024. PMID: 38181752 Free PMC article. Review.
Human conjunctiva organoids to study ocular surface homeostasis and disease.
Bannier-Hélaouët M, Korving J, Ma Z, Begthel H, Giladi A, Lamers MM, van de Wetering WJ, Yawata N, Yawata M, LaPointe VLS, Dickman MM, Kalmann R, Imhoff SM, van Es JH, López-Iglesias C, Peters PJ, Haagmans BL, Wu W, Clevers H. Bannier-Hélaouët M, et al. Among authors: clevers h. Cell Stem Cell. 2024 Feb 1;31(2):227-243.e12. doi: 10.1016/j.stem.2023.12.008. Epub 2024 Jan 11. Cell Stem Cell. 2024. PMID: 38215738 Free article.
Optimized human intestinal organoid model reveals interleukin-22-dependency of paneth cell formation.
He GW, Lin L, DeMartino J, Zheng X, Staliarova N, Dayton T, Begthel H, van de Wetering WJ, Bodewes E, van Zon J, Tans S, Lopez-Iglesias C, Peters PJ, Wu W, Kotlarz D, Klein C, Margaritis T, Holstege F, Clevers H. He GW, et al. Among authors: clevers h. Cell Stem Cell. 2022 Dec 1;29(12):1718-1720. doi: 10.1016/j.stem.2022.11.001. Cell Stem Cell. 2022. PMID: 36459971 Free PMC article. No abstract available.
821 results