Ciccone A - Search Results

1

Lipid order and charge protect killer T cells from accidental death.

Rudd-Schmidt JA, Hodel AW, Noori T, Lopez JA, Cho HJ, Verschoor S, Ciccone A, Trapani JA, Hoogenboom BW, Voskoboinik I. Rudd-Schmidt JA, et al. Among authors: ciccone a. Nat Commun. 2019 Nov 27;10(1):5396. doi: 10.1038/s41467-019-13385-x. Nat Commun. 2019. PMID: 31776337 Free PMC article.

2

The structural basis for membrane binding and pore formation by lymphocyte perforin.

Law RH, Lukoyanova N, Voskoboinik I, Caradoc-Davies TT, Baran K, Dunstone MA, D'Angelo ME, Orlova EV, Coulibaly F, Verschoor S, Browne KA, Ciccone A, Kuiper MJ, Bird PI, Trapani JA, Saibil HR, Whisstock JC. Law RH, et al. Among authors: ciccone a. Nature. 2010 Nov 18;468(7322):447-51. doi: 10.1038/nature09518. Epub 2010 Oct 31. Nature. 2010. PMID: 21037563

3

Calcium-dependent plasma membrane binding and cell lysis by perforin are mediated through its C2 domain: A critical role for aspartate residues 429, 435, 483, and 485 but not 491.

Voskoboinik I, Thia MC, Fletcher J, Ciccone A, Browne K, Smyth MJ, Trapani JA. Voskoboinik I, et al. Among authors: ciccone a. J Biol Chem. 2005 Mar 4;280(9):8426-34. doi: 10.1074/jbc.M413303200. Epub 2004 Dec 2. J Biol Chem. 2005. PMID: 15576364 Free article.

4

Cytotoxic T lymphocyte-induced killing in the absence of granzymes A and B is unique and distinct from both apoptosis and perforin-dependent lysis.

Waterhouse NJ, Sutton VR, Sedelies KA, Ciccone A, Jenkins M, Turner SJ, Bird PI, Trapani JA. Waterhouse NJ, et al. Among authors: ciccone a. J Cell Biol. 2006 Apr 10;173(1):133-44. doi: 10.1083/jcb.200510072. J Cell Biol. 2006. PMID: 16606695 Free PMC article.

5

Cytotoxic T lymphocytes from cathepsin B-deficient mice survive normally in vitro and in vivo after encountering and killing target cells.

Baran K, Ciccone A, Peters C, Yagita H, Bird PI, Villadangos JA, Trapani JA. Baran K, et al. Among authors: ciccone a. J Biol Chem. 2006 Oct 13;281(41):30485-91. doi: 10.1074/jbc.M602007200. Epub 2006 Aug 16. J Biol Chem. 2006. PMID: 16914553 Free article.

6

Perforin activity and immune homeostasis: the common A91V polymorphism in perforin results in both presynaptic and postsynaptic defects in function.

Voskoboinik I, Sutton VR, Ciccone A, House CM, Chia J, Darcy PK, Yagita H, Trapani JA. Voskoboinik I, et al. Among authors: ciccone a. Blood. 2007 Aug 15;110(4):1184-90. doi: 10.1182/blood-2007-02-072850. Epub 2007 May 2. Blood. 2007. PMID: 17475905 Free article.

7

The molecular basis for perforin oligomerization and transmembrane pore assembly.

Baran K, Dunstone M, Chia J, Ciccone A, Browne KA, Clarke CJ, Lukoyanova N, Saibil H, Whisstock JC, Voskoboinik I, Trapani JA. Baran K, et al. Among authors: ciccone a. Immunity. 2009 May;30(5):684-95. doi: 10.1016/j.immuni.2009.03.016. Epub 2009 May 14. Immunity. 2009. PMID: 19446473 Free article.

8

Protection from endogenous perforin: glycans and the C terminus regulate exocytic trafficking in cytotoxic lymphocytes.

Brennan AJ, Chia J, Browne KA, Ciccone A, Ellis S, Lopez JA, Susanto O, Verschoor S, Yagita H, Whisstock JC, Trapani JA, Voskoboinik I. Brennan AJ, et al. Among authors: ciccone a. Immunity. 2011 Jun 24;34(6):879-92. doi: 10.1016/j.immuni.2011.04.007. Epub 2011 Jun 9. Immunity. 2011. PMID: 21658975 Free article.

9

Defining the interaction of perforin with calcium and the phospholipid membrane.

Traore DA, Brennan AJ, Law RH, Dogovski C, Perugini MA, Lukoyanova N, Leung EW, Norton RS, Lopez JA, Browne KA, Yagita H, Lloyd GJ, Ciccone A, Verschoor S, Trapani JA, Whisstock JC, Voskoboinik I. Traore DA, et al. Among authors: ciccone a. Biochem J. 2013 Dec 15;456(3):323-35. doi: 10.1042/BJ20130999. Biochem J. 2013. PMID: 24070258

10

Perforin proteostasis is regulated through its C2 domain: supra-physiological cell death mediated by T431D-perforin.

Brennan AJ, Law RHP, Conroy PJ, Noori T, Lukoyanova N, Saibil H, Yagita H, Ciccone A, Verschoor S, Whisstock JC, Trapani JA, Voskoboinik I. Brennan AJ, et al. Among authors: ciccone a. Cell Death Differ. 2018 Aug;25(8):1517-1529. doi: 10.1038/s41418-018-0057-z. Epub 2018 Feb 7. Cell Death Differ. 2018. PMID: 29416110 Free PMC article.

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