Christensen SB - Search Results

1

Large Scale Conversion of Trilobolide into the Payload of Mipsagargin: 8-O-(12-Aminododecanoyl)-8-O-Debutanoylthapsigargin.

Zimmermann T, Drašar P, Rimpelová S, Christensen SB, Khripach VA, Jurášek M. Zimmermann T, et al. Among authors: christensen sb. Biomolecules. 2020 Dec 5;10(12):1640. doi: 10.3390/biom10121640. Biomolecules. 2020. PMID: 33291419 Free PMC article.

2

Preparation of Enzyme-Activated Thapsigargin Prodrugs by Solid-Phase Synthesis.

Zimmermann T, Christensen SB, Franzyk H. Zimmermann T, et al. Among authors: christensen sb. Molecules. 2018 Jun 15;23(6):1463. doi: 10.3390/molecules23061463. Molecules. 2018. PMID: 29914143 Free PMC article.

3

Phorbol Rearrangements.

Zimmermann T, Franzyk H, Christensen SB. Zimmermann T, et al. Among authors: christensen sb. J Nat Prod. 2018 Sep 28;81(9):2134-2137. doi: 10.1021/acs.jnatprod.8b00607. Epub 2018 Sep 14. J Nat Prod. 2018. PMID: 30216064

4

Missing Selectivity of Targeted 4β-Phorbol Prodrugs Expected to be Potential Chemotherapeutics.

Tarvainen I, Zimmermann T, Heinonen P, Jäntti MH, Yli-Kauhaluoma J, Talman V, Franzyk H, Tuominen RK, Christensen SB. Tarvainen I, et al. Among authors: christensen sb. ACS Med Chem Lett. 2019 Dec 23;11(5):671-677. doi: 10.1021/acsmedchemlett.9b00554. eCollection 2020 May 14. ACS Med Chem Lett. 2019. PMID: 32435369 Free PMC article.

5

Mipsagargin: The Beginning-Not the End-of Thapsigargin Prodrug-Based Cancer Therapeutics.

Isaacs JT, Brennen WN, Christensen SB, Denmeade SR. Isaacs JT, et al. Among authors: christensen sb. Molecules. 2021 Dec 9;26(24):7469. doi: 10.3390/molecules26247469. Molecules. 2021. PMID: 34946547 Free PMC article. Review.

6

Targeting thapsigargin towards tumors.

Doan NT, Paulsen ES, Sehgal P, Møller JV, Nissen P, Denmeade SR, Isaacs JT, Dionne CA, Christensen SB. Doan NT, et al. Among authors: christensen sb. Steroids. 2015 May;97:2-7. doi: 10.1016/j.steroids.2014.07.009. Epub 2014 Jul 24. Steroids. 2015. PMID: 25065587 Free PMC article. Review.

7

Thapsigargin, Origin, Chemistry, Structure-Activity Relationships and Prodrug Development.

Quynh Doan NT, Christensen SB. Quynh Doan NT, et al. Among authors: christensen sb. Curr Pharm Des. 2015;21(38):5501-17. doi: 10.2174/1381612821666151002112824. Curr Pharm Des. 2015. PMID: 26429715 Review.

8

From Plant to Patient: Thapsigargin, a Tool for Understanding Natural Product Chemistry, Total Syntheses, Biosynthesis, Taxonomy, ATPases, Cell Death, and Drug Development.

Christensen SB, Simonsen HT, Engedal N, Nissen P, Møller JV, Denmeade SR, Isaacs JT. Christensen SB, et al. Prog Chem Org Nat Prod. 2021;115:59-114. doi: 10.1007/978-3-030-64853-4_2. Prog Chem Org Nat Prod. 2021. PMID: 33797641

9

Elucidation of the topography of the thapsigargin binding site in the sarco-endoplasmic calcium ATPase.

Skytte DM, Møller JV, Liu H, Nielsen HØ, Svenningsen LE, Jensen CM, Olsen CE, Christensen SB. Skytte DM, et al. Among authors: christensen sb. Bioorg Med Chem. 2010 Aug 1;18(15):5634-46. doi: 10.1016/j.bmc.2010.06.032. Epub 2010 Jun 16. Bioorg Med Chem. 2010. PMID: 20615710

10

Structure/activity relationship of thapsigargin inhibition on the purified Golgi/secretory pathway Ca²⁺/Mn²⁺-transport ATPase (SPCA1a).

Chen J, De Raeymaecker J, Hovgaard JB, Smaardijk S, Vandecaetsbeek I, Wuytack F, Møller JV, Eggermont J, De Maeyer M, Christensen SB, Vangheluwe P. Chen J, et al. Among authors: christensen sb. J Biol Chem. 2017 Apr 28;292(17):6938-6951. doi: 10.1074/jbc.M117.778431. Epub 2017 Mar 6. J Biol Chem. 2017. PMID: 28264934 Free PMC article.

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