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Modulators of CFTR. Updates on clinical development and future directions.
Bardin E, Pastor A, Semeraro M, Golec A, Hayes K, Chevalier B, Berhal F, Prestat G, Hinzpeter A, Gravier-Pelletier C, Pranke I, Sermet-Gaudelus I. Bardin E, et al. Among authors: chevalier b. Eur J Med Chem. 2021 Mar 5;213:113195. doi: 10.1016/j.ejmech.2021.113195. Epub 2021 Jan 16. Eur J Med Chem. 2021. PMID: 33524685 Review.
Factors influencing readthrough therapy for frequent cystic fibrosis premature termination codons.
Pranke I, Bidou L, Martin N, Blanchet S, Hatton A, Karri S, Cornu D, Costes B, Chevalier B, Tondelier D, Girodon E, Coupet M, Edelman A, Fanen P, Namy O, Sermet-Gaudelus I, Hinzpeter A. Pranke I, et al. Among authors: chevalier b. ERJ Open Res. 2018 Feb 23;4(1):00080-2017. doi: 10.1183/23120541.00080-2017. eCollection 2018 Jan. ERJ Open Res. 2018. PMID: 29497617 Free PMC article.
Targeting different binding sites in the CFTR structures allows to synergistically potentiate channel activity.
Froux L, Elbahnsi A, Boucherle B, Billet A, Baatallah N, Hoffmann B, Alliot J, Zelli R, Zeinyeh W, Haudecoeur R, Chevalier B, Fortuné A, Mirval S, Simard C, Lehn P, Mornon JP, Hinzpeter A, Becq F, Callebaut I, Décout JL. Froux L, et al. Among authors: chevalier b. Eur J Med Chem. 2020 Mar 15;190:112116. doi: 10.1016/j.ejmech.2020.112116. Epub 2020 Feb 9. Eur J Med Chem. 2020. PMID: 32078860
New insights into structure and function of bis-phosphinic acid derivatives and implications for CFTR modulation.
Bitam S, Elbahnsi A, Creste G, Pranke I, Chevalier B, Berhal F, Hoffmann B, Servel N, Baatalah N, Tondelier D, Hatton A, Moquereau C, Faria Da Cunha M, Pastor A, Lepissier A, Hinzpeter A, Mornon JP, Prestat G, Edelman A, Callebaut I, Gravier-Pelletier C, Sermet-Gaudelus I. Bitam S, et al. Among authors: chevalier b. Sci Rep. 2021 Mar 25;11(1):6842. doi: 10.1038/s41598-021-83240-x. Sci Rep. 2021. PMID: 33767236 Free PMC article.
Author Correction: New insights into structure and function of bis-phosphinic acid derivatives and implications for CFTR modulation.
Bitam S, Elbahnsi A, Creste G, Pranke I, Chevalier B, Berhal F, Hoffmann B, Servel N, Baatalah N, Tondelier D, Hatton A, Moquereau C, Faria Da Cunha M, Pastor A, Lepissier A, Hinzpeter A, Mornon JP, Prestat G, Edelman A, Callebaut I, Gravier-Pelletier C, Sermet-Gaudelus I. Bitam S, et al. Among authors: chevalier b. Sci Rep. 2021 Sep 15;11(1):18709. doi: 10.1038/s41598-021-98301-4. Sci Rep. 2021. PMID: 34526640 Free PMC article. No abstract available.
Pharmacological chaperones improve intra-domain stability and inter-domain assembly via distinct binding sites to rescue misfolded CFTR.
Baatallah N, Elbahnsi A, Mornon JP, Chevalier B, Pranke I, Servel N, Zelli R, Décout JL, Edelman A, Sermet-Gaudelus I, Callebaut I, Hinzpeter A. Baatallah N, et al. Among authors: chevalier b. Cell Mol Life Sci. 2021 Dec;78(23):7813-7829. doi: 10.1007/s00018-021-03994-5. Epub 2021 Oct 29. Cell Mol Life Sci. 2021. PMID: 34714360 Free article.
Reclassifying inconclusive diagnosis after newborn screening for cystic fibrosis. Moving forward.
Hatton A, Bergougnoux A, Zybert K, Chevalier B, Mesbahi M, Altéri JP, Walicka-Serzysko K, Postek M, Taulan-Cadars M, Edelman A, Hinzpeter A, Claustres M, Girodon E, Raynal C, Sermet-Gaudelus I, Sands D. Hatton A, et al. Among authors: chevalier b. J Cyst Fibros. 2022 May;21(3):448-455. doi: 10.1016/j.jcf.2021.12.010. Epub 2021 Dec 21. J Cyst Fibros. 2022. PMID: 34949556 Free article.
468 results