Chène P - Search Results

1

Discovery of a novel class of highly potent inhibitors of the p53-MDM2 interaction by structure-based design starting from a conformational argument.

Furet P, Masuya K, Kallen J, Stachyra-Valat T, Ruetz S, Guagnano V, Holzer P, Mah R, Stutz S, Vaupel A, Chène P, Jeay S, Schlapbach A. Furet P, et al. Among authors: chene p. Bioorg Med Chem Lett. 2016 Oct 1;26(19):4837-4841. doi: 10.1016/j.bmcl.2016.08.010. Epub 2016 Aug 9. Bioorg Med Chem Lett. 2016. PMID: 27542305

2

A small synthetic peptide, which inhibits the p53-hdm2 interaction, stimulates the p53 pathway in tumour cell lines.

Chène P, Fuchs J, Bohn J, García-Echeverría C, Furet P, Fabbro D. Chène P, et al. J Mol Biol. 2000 May 26;299(1):245-53. doi: 10.1006/jmbi.2000.3738. J Mol Biol. 2000. PMID: 10860736

3

Discovery of potent antagonists of the interaction between human double minute 2 and tumor suppressor p53.

García-Echeverría C, Chène P, Blommers MJ, Furet P. García-Echeverría C, et al. Among authors: chene p. J Med Chem. 2000 Aug 24;43(17):3205-8. doi: 10.1021/jm990966p. J Med Chem. 2000. PMID: 10966738 No abstract available.

4

Coupling of the antennapedia third helix to a potent antagonist of the p53/hdm2 protein-protein interaction.

García-Echeverría C, Furet P, Chène P. García-Echeverría C, et al. Among authors: chene p. Bioorg Med Chem Lett. 2001 Aug 20;11(16):2161-4. doi: 10.1016/s0960-894x(01)00394-8. Bioorg Med Chem Lett. 2001. PMID: 11514160

5

Study of the cytotoxic effect of a peptidic inhibitor of the p53-hdm2 interaction in tumor cells.

Chène P, Fuchs J, Carena I, Furet P, García-Echeverría C. Chène P, et al. FEBS Lett. 2002 Oct 9;529(2-3):293-7. doi: 10.1016/s0014-5793(02)03362-8. FEBS Lett. 2002. PMID: 12372616 Free article.

6

Inhibiting the p53-MDM2 interaction: an important target for cancer therapy.

Chène P. Chène P. Nat Rev Cancer. 2003 Feb;3(2):102-9. doi: 10.1038/nrc991. Nat Rev Cancer. 2003. PMID: 12563309 Review.

7

Targeting p53 in cancer.

Chène P. Chène P. Curr Med Chem Anticancer Agents. 2001 Aug;1(2):151-61. doi: 10.2174/1568011013354741. Curr Med Chem Anticancer Agents. 2001. PMID: 12678764 Review.

8

Inhibition of the p53-MDM2 interaction: targeting a protein-protein interface.

Chène P. Chène P. Mol Cancer Res. 2004 Jan;2(1):20-8. Mol Cancer Res. 2004. PMID: 14757842 Review.

9

Inhibition of the p53-hdm2 interaction with low molecular weight compounds.

Chène P. Chène P. Cell Cycle. 2004 Apr;3(4):460-1. doi: 10.4161/cc.3.4.791. Epub 2004 Apr 1. Cell Cycle. 2004. PMID: 14976429

10

Inhibition of DNA helicases with DNA-competitive inhibitors.

Dubaele S, Jahnke W, Schoepfer J, Fuchs J, Chène P. Dubaele S, et al. Among authors: chene p. Bioorg Med Chem Lett. 2006 Feb 15;16(4):923-7. doi: 10.1016/j.bmcl.2005.10.110. Epub 2005 Nov 21. Bioorg Med Chem Lett. 2006. PMID: 16300943

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